S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Clinical Medical Sciences (임상의과학과) Theses (Master's Degree_임상의과학과)
Anti-adhesive Effect and Safety of Sodium Hyaluronate-Carboxymethyl Cellulose Membrane in Thyroid Surgery
갑상선 절제 수술에서 Sodium Hyaluronate-Carboxymethyl Cellulose Membrane의 유착 방지 효과와 안전성
- 의과대학 임상의과학과
- Issue Date
- 서울대학교 대학원
- 학위논문 (석사)-- 서울대학교 대학원 : 임상의과학과, 2013. 2. 한원식.
A number of researchers have suggested the use of sodium hyaluronate carboxymethyl cellulose (HA-CMC) membrane for preventing postoperative adhesion. This study evaluated the anti-adhesive effect and safety of the HA-CMC membrane in thyroidectomy for papillary thyroid cancer.
One hundred sixty two patients who underwent thyroidectomy were prospectively randomized. In the study group of 80 patients, the 7.5 x 13cm HA-CMC membrane was applied to the operative field after thyroidectomy. The subjects were asked about complications including adhesive symptoms using a 8-item questionnaire at 2 weeks, 3 months and 6 months after surgery.
In addition, items on the appearance of neck wrinkles and scars were evaluated by a physician who had no information about the patient’s allocation.
There were no significant differences in complications such as swallowing difficulty, and wrinkles between study and control groups. Both groups presented significantly decreased scores over time in swallowing difficulty, and wrinkles. There were no complications regarding to the HA-CMC solution.
The HA-CMC membrane did not decrease subjective or objective postoperative adhesion in patients undergoing thyroid surgery, although it was biologically safe.