S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Medicine (의학과) Theses (Master's Degree_의학과)
Several factors contributing to variations of T1 ρ mapping of articular cartilage
관절연골의 T1ρ 이완시간에 영향을 미치는 다양한 요소들에 대한 연구
- 의과대학 의학과
- Issue Date
- 서울대학교 대학원
- 학위논문 (석사)-- 서울대학교 대학원 : 의학과, 2014. 8. 홍성환.
- Introduction: Degenerative arthritis is a very common and important disease that is characterized by decreasing proteoglycan and collagen fibers in the articular cartilage. Early detection of degeneration and prediction of the development of advanced osteoarthritis are important for planning the treatment of osteoarthritis patients. The purpose of this study is to evaluate various factors that contribute to variations in the T1 ρ value of articular cartilage.
Methods: This study was exempted from institutional and animal review board reviews, and informed consent was not required. Twelve porcine patellae were assigned into the following three groups: trypsin-treated (proteoglycan-degraded), collagenase-treated (collagen-degraded), and control groups. T1 ρ imaging was obtained using 3 Tesla magnetic resonance imaging(MRI) scanners with a single loop coil at the three different orientations with respect to the main magnetic field. The T1 ρ relaxation map of articular cartilage was constructed with a homemade mapping program using Mat lab R2013. Significant differences were explored using the ANCOVA test to evaluate the effects of the enzyme and orientation on the T1 ρ relaxation time.
Results: There was a statistically significant difference in the T1 ρ values among the three different enzyme groups (P<0.001). However, there was no significant difference in the T1 ρ values among the three different orientations (P=0.220).
Conclusions: Degradation of the proteoglycans or collagen fibers in the articular cartilage caused an increase in the T1 ρ value of articular cartilage, but the orientation dependence of the T1 ρ value was not proven.