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Aging and neurodegeneration. Molecular mechanisms of neuronal loss in Huntington's disease

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dc.contributor.authorLee, Soon-Tae-
dc.contributor.authorKim, Manho-
dc.date.accessioned2009-11-18T06:41:56Z-
dc.date.available2009-11-18T06:41:56Z-
dc.date.issued2006-03-11-
dc.identifier.citationMech Ageing Dev. 2006 May;127(5):432-5. Epub 2006 Mar 9.en
dc.identifier.issn0047-6374 (Print)-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T31-4JF8H6C-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=7e999a7bbc23fcd40f019f743bd01b64-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16527334-
dc.identifier.urihttp://hdl.handle.net/10371/13274-
dc.description.abstractHuntington's disease (HD) is a fatal, genetically based late-onset neurodegenerative disorder in which a loss of neostriatal neurons is a main characteristic. The CAG trinucleotide repeat expansion encoding polyglutamine tract induces progressive deficits in intra- and inter-cellular signalling, and subsequent clinical signs developed with aging process. CAG-induced neurodegeneration and disease-onset shows aging-dependent pattern. Proposed mechanism of neurodegeneration includes intranuclear or intracellular protein aggregates, proteolytic cleavage of huntingtin (cf. caspase, calpain), altered transcription or other neurotransmitter signalling deficits. Recently, stem cell transplantation is of benefit to protect neurons against neurodegeneration and recover the functional deficit in the experimental HD model. This review focuses on current knowledge of molecular mechanisms in neurodegeneration and potential therapeutic targets in HD.en
dc.language.isoenen
dc.publisherElsevieren
dc.subject*Agingen
dc.subjectAnimalsen
dc.subjectCaspases/metabolismen
dc.subjectEnzyme Activationen
dc.subjectHumansen
dc.subjectHuntington Disease/*pathologyen
dc.subject*Nerve Degenerationen
dc.subjectNerve Tissue Proteins/geneticsen
dc.subjectNeurodegenerative Diseases/*pathologyen
dc.subjectNeurons/metabolism/*pathologyen
dc.subjectNuclear Proteins/geneticsen
dc.titleAging and neurodegeneration. Molecular mechanisms of neuronal loss in Huntington's diseaseen
dc.typeArticleen
dc.contributor.AlternativeAuthor이순태-
dc.contributor.AlternativeAuthor김만호-
dc.identifier.doi10.1016/j.mad.2006.01.022-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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