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Simple measurement of spinal cord evoked potential: a valuable data source in the rat spinal cord injury model

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Authors
Park, Jong-Pil; Kim, Ki-Jeong; Phi, Ji Hoon; Park, Chul-Kee; Kim, Jong-Hoon; Kang, Hyo Jin; Lee, Dohun; Han, Kyu Hyun; Wang, Kyu-Chang; Paek, Sun Ha
Issue Date
2007-08-28
Publisher
Elsevier
Citation
J Clin Neurosci. 2007 Nov;14(11):1099-105. Epub 2007 Aug 24.
Keywords
AnimalsDisease Models, AnimalElectrodesEvoked Potentials, Motor/*physiologyFemaleLocomotion/physiologyPredictive Value of TestsPyramidal Tracts/pathology/*physiologyRatsRats, Sprague-DawleyReaction Time/physiologyRecovery of Function/physiologySpinal Cord Injuries/pathology/*physiopathology
Abstract
Measurement of spinal cord evoked potentials (SCEPs) is proposed as a means of predicting locomotion outcome in the rat spinal cord injury (SCI) model. Using 55 rats, three reproducible peak waves (waves I, II and III) were observed during stimulation at the C7 level with recording at the L1 epidural space. Hemisection at the T13 level showed three wave loss patterns: wave III loss only, loss of both wave II and III, and loss of all three waves. Defining an ideal SCI model as establishment of stable monoparesis or paraparesis, all animals in the wave II-III loss group showed favorable results. Histological data and electrophysiological properties allowed reasonable assumptions of wave origin: wave I from extrapyramidal tracts, wave II from the ventral corticospinal tract, and wave III from the dorsal corticospinal tract. Complete destruction of pyramidal tracts in both dorsal and ventral fibers was essential for long-term impairment of locomotion.
ISSN
0967-5868 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WHP-4PGXF40-1&_user=404106&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000019238&_version=1&_urlVersion=0&_userid=404106&md5=fb36442cead3e816d038af5cef4e2447

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17719789

http://hdl.handle.net/10371/13277
DOI
https://doi.org/10.1016/j.jocn.2006.10.007
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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