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Gombamide A, a Cyclic Thiopeptide from the Sponge Clathria gombawuiensis
Clathria gombawuiensis 한국해면에서 분리한 신규 Peptide

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Authors
우정균
Advisor
신종헌
Major
약학대학 제약학과
Issue Date
2014
Publisher
서울대학교 대학원
Keywords
Clathria gombawuiensisa Cyclic C-terminally-modified Thiohexapeptidethe Unusual Amino Acid Residues
Description
학위논문 (석사)-- 서울대학교 대학원 : 제약학과, 2014. 2. 신종헌.
Abstract
A new peptide, gombamide A (1), was isolated from the marine sponge Clathria gombawuiensis, collected from Korean waters. Based on the results of combined spectroscopic analyses, the structure of this compound was determined to be a cyclic C-terminally-modified thiohexapeptide containing the unusual amino acid residues para-hydroxystyrylamide (pHSA) and pyroglutamicacid (pyroGlu). The absolute configurations of all amino acid residues were determined to be L by advanced Marfey’s analysis. The new compound exhibited weak cytotoxicity against A549 and K562 cell lines as well as moderate inhibitory activity against Na+/K+-ATPase.
Language
English
URI
http://hdl.handle.net/10371/133429
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College of Pharmacy (약학대학)Dept. of Manufacturing Pharmacy (제약학과)Theses (Master's Degree_제약학과)
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