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Functional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary intervention

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dc.contributor.authorCho, Hyun-Jai-
dc.contributor.authorChae, In-Ho-
dc.contributor.authorPark, Kyung-Woo-
dc.contributor.authorJu, Jae-Ran-
dc.contributor.authorOh, Seil-
dc.contributor.authorLee, Myoung-Mook-
dc.contributor.authorPark, Young-Bae-
dc.date.accessioned2009-11-18T07:41:30Z-
dc.date.available2009-11-18T07:41:30Z-
dc.date.issued2002-03-28-
dc.identifier.citationJ Hum Genet. 2002;47(2):88-91.en
dc.identifier.govdochttp://dx.doi.org/10.1007/s100380200006-
dc.identifier.issn1434-5161 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11916008-
dc.identifier.urihttp://hdl.handle.net/10371/13361-
dc.description.abstractThe matrix metalloproteinases appear to play an important role in the development and progression of atherosclerotic lesions. We studied the C-1562T polymorphism of the gelatinase B promoter in relation to coronary artery disease and restenosis after a percutaneous coronary intervention (PCI) in Koreans. To determine the frequency of the C-1562T allele, we examined 63 patients with coronary artery disease who underwent both PCI and 6-month follow-up coronary angiograms (CAGs), and 67 control patients with a normal CAG with respect to their clinical data and genotype. Frequencies of the C/C homozygotes and the non-C/C heterozygotes and homozygotes (C/T and T/T) were 94% and 6% in the normal CAG group, and 76.2% and 23.8% in the patient group, respectively. This gave a relative risk of 0.203 (95% CI: 0.063-0.651, P = 0.005) for coronary artery disease when the C/C genotype was compared with the non-C/C genotype. In the patient groups, the allele frequencies of the C/C and non-C/C were 80% and 20% in the nonrestenotic subgroup, and 71.4% and 28.6% in the restenotic subgroup (P = 0.554). No T/T homozygote was found in any of the groups. We conclude that C/C homozygosity is a potential genetic protective factor for coronary artery disease in Koreans.en
dc.language.isoen-
dc.publisherSpringer Verlagen
dc.subject*Angioplasty, Transluminal, Percutaneous Coronaryen
dc.subjectCoronary Artery Disease/enzymology/*geneticsen
dc.subjectCoronary Restenosis/enzymology/*geneticsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMatrix Metalloproteinase 9/*genetics/metabolismen
dc.subjectMiddle Ageden
dc.subject*Polymorphism, Geneticen
dc.subjectPromoter Regions, Genetic/*geneticsen
dc.titleFunctional polymorphism in the promoter region of the gelatinase B gene in relation to coronary artery disease and restenosis after percutaneous coronary interventionen
dc.typeArticleen
dc.contributor.AlternativeAuthor조현재-
dc.contributor.AlternativeAuthor채인호-
dc.contributor.AlternativeAuthor박경우-
dc.contributor.AlternativeAuthor주재란-
dc.contributor.AlternativeAuthor오세일-
dc.contributor.AlternativeAuthor이명묵-
dc.contributor.AlternativeAuthor박영배-
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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