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Stereoselective Synthesis of D-5-Homo-4-selenonucleosides as Potent Therapeutic Agents : 효과적인 치료제로서의 D-5-Homo-4-selenonucleosides의 입체 선택적 합성
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- Authors
- Advisor
- 정낙신
- Major
- 약학대학 약학과
- Issue Date
- 2016-02
- Publisher
- 서울대학교 대학원
- Keywords
- D-5’-Homo-4’-selenonucleosides ; Sharpless asymmetric epoxidation ; Regioselective cleavage ; Stereoselective reduction
- Description
- 학위논문 (석사)-- 서울대학교 대학원 : 약학대학 약학과 약품화학전공, 2016. 2. 정낙신.
- Abstract
- D-5-Homo-4-selenonucleosides were synthesized from D-5-homo-4-selenoribose using a Pummerer-type condensation. For the stereoselective synthesis of the key intermediate D-5-homo-4-selenoribose, we employed Sharpless asymmetric epoxidation, regioselective epoxide cleavage, and stereoselective reduction of the ketone as the key steps.
- Language
- English
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