Structure elucidation of new polyketide-derived secondary metabolites from bacteria in extreme habitats

Abstract

Bacteria inhabiting extreme environments have been considered as attracting resources for bioactive compounds. As part of continuing efforts to explore the chemical diversity of bacteria from extreme habitats for drug discovery, in this study, bacterial strains inhabiting saltern and Alaskan permafrost have been investigated. Actinobacterial strains were isolated from these extreme habitats, cultivated, and chemically analyzed by LC/MS. Based on the bacterial chemical profiles acquired by LC/MS analysis, four new polyketide-derived compounds including three new macrolides and an oxazole-bearing compound were discovered. The structures of the new natural products were elucidated by the analysis of spectroscopic data such as 1D and 2D NMR, mass, UV, and IR spectra.