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Adipose Tissue Inflammation in Weight Cycling Mice

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Authors
성혜림
Advisor
성제경
Major
수의과대학 수의학과
Issue Date
2016
Publisher
서울대학교 대학원
Keywords
ObesityWeight cyclingAdipose tissueInflammation
Description
학위논문 (석사)-- 서울대학교 대학원 : 수의학과 수의생명과학 전공, 2016. 8. 성제경.
Abstract
Obesity correlates with the development of metabolic diseases, and weight loss is the ideal approach to ameliorate obesity. However, weight loss is rarely maintained, leading to weight regain. This phenomenon, termed ‘weight cycling’, is also known as ‘yo-yo dieting’. Weight cycling increases the risk of morbidity and mortality in both humans and mice, although the mechanisms that regulate weight cycling are not well understood. We subjected mice to a diet-switch protocol, designed to induce weight cycling, to determine the differences between mice that undergo weight cycling and mice that experience weight gain without weight cycling. Weight cycling produced aggravated metabolic phenotypes including increased body weight and dyslipidemia. Weight cycling produced severe adipose tissue inflammation, including hypertrophic adipocytes, and an increased number of crown-like structures. Upon weight cycling, invasive immune cells in adipose tissue entered a pro-inflammatory state. Therefore, the metabolic phenotype was much severely aggravated, and adipose inflammation was significantly increased, in the weight cycling group compared to the weight gain group. In addition, the expression of multiple immune-related genes and pro-inflammatory cytokine genes was elevated in the weight cycling group, compared to the weight gain group. These studies indicate that altered immune cell populations and gene expression patterns in adipose tissue may contribute to metabolic aggravation during weight cycling.
Language
English
URI
http://hdl.handle.net/10371/133755
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Theses (Master's Degree_수의학과)
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