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Efficacy of low-dose clarithromycin triple therapy and tinidazole-containing triple therapy for Helicobacter pylori eradication

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dc.contributor.authorChoi, I J-
dc.contributor.authorJung, H C-
dc.contributor.authorChoi, K W-
dc.contributor.authorKim, J H-
dc.contributor.authorAhn, D S-
dc.contributor.authorYang, U S-
dc.contributor.authorRew, J S-
dc.contributor.authorLee, S I-
dc.contributor.authorRhee, J C-
dc.contributor.authorChung, I S-
dc.contributor.authorChung, J M-
dc.contributor.authorHong, W-S-
dc.date.accessioned2009-11-18T07:53:56Z-
dc.date.available2009-11-18T07:53:56Z-
dc.date.issued2002-02-22-
dc.identifier.citationAliment Pharmacol Ther. 2002 Jan;16(1):145-51.en
dc.identifier.issn0269-2813 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11856089-
dc.identifier.urihttp://hdl.handle.net/10371/13413-
dc.description.abstractBACKGROUND: Proton pump inhibitor-based triple therapies are recommended as the first-line treatment for Helicobacter pylori eradication. AIM: To evaluate the efficacies of low-dose clarithromycin triple therapy and tinidazole-containing triple therapy in a metronidazole resistance prevalent area and to compare the efficacies with standard triple therapy. METHODS: In a randomized, multicentre, prospective study, a total of 352 patients with duodenal ulcer or non-ulcer dyspepsia were randomly divided into three groups according to the administered regimen: OAC250 group (omeprazole, 20 mg, amoxicillin, 1000 mg, and clarithromycin, 250 mg), OAC500 group (omeprazole, 20 mg, amoxicillin, 1000 mg, and clarithromycin, 500 mg) and OTC group (omeprazole, 20 mg, tinidazole, 500 mg, and clarithromycin, 500 mg). The three groups received each regimen twice daily for 7 days. Upper gastrointestinal endoscopy was performed before and 4 weeks after treatment. H. pylori status was determined by rapid urease test and 13C urea breath test. RESULTS: The eradication rates in the OAC250, OAC500 and OTC groups were 76.2%, 65.7% and 64.8% (95% confidence interval: 67.9-84.4%, 56.7-74.8% and 55.7-73.9%), respectively, by intention-to-treat analysis (P=0.149) and 92.8%, 87.2% and 84.1% (95% confidence interval: 84.4-97.3%, 77.9-93.8% and 73.9-91.2%), respectively, by per protocol analysis (P=0.088). All regimens were well tolerated and compliance was excellent. CONCLUSIONS: Both low-dose clarithromycin triple therapy and tinidazole-containing triple therapy are effective and safe regimens for H. pylori eradication.en
dc.language.isoen-
dc.publisherWiley-Blackwellen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAmoxicillin/administration & dosage/*pharmacologyen
dc.subjectAnti-Bacterial Agents/administration & dosage/*pharmacologyen
dc.subjectAnti-Ulcer Agents/administration & dosage/*pharmacologyen
dc.subjectAntitrichomonal Agents/administration & dosage/*pharmacologyen
dc.subjectBreath Testsen
dc.subjectClarithromycin/administration & dosage/*pharmacologyen
dc.subjectDrug Resistanceen
dc.subjectDrug Therapy, Combinationen
dc.subjectDuodenal Ulcer/microbiologyen
dc.subjectDyspepsia/etiologyen
dc.subjectEndoscopy, Gastrointestinalen
dc.subjectFemaleen
dc.subjectHelicobacter Infections/*drug therapyen
dc.subjectHelicobacter pylori/drug effects/pathogenicityen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOmeprazole/administration & dosage/*pharmacologyen
dc.subjectPenicillins/administration & dosage/*pharmacologyen
dc.subjectProspective Studiesen
dc.subjectTinidazole/administration & dosage/*pharmacologyen
dc.subjectTreatment Outcomeen
dc.subjectUrea/analysisen
dc.titleEfficacy of low-dose clarithromycin triple therapy and tinidazole-containing triple therapy for Helicobacter pylori eradicationen
dc.typeArticleen
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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