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Heat shock protein 27 reduces phosphorylated tau and rescues cell death in human neuroblastoma cell line SH-SY5Y

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Authors
안준성
Advisor
박종상
Major
자연과학대학 화학부
Issue Date
2013-02
Publisher
서울대학교 대학원
Keywords
Hyperphosphorylated tauAlzheimer’s diseaseHsp27SH-SY5Y
Description
학위논문 (석사)-- 서울대학교 대학원 : 화학부 생화학 전공, 2013. 2. 박종상.
Abstract
The two pathological hallmarks characterizing Alzheimer’s disease are the formation of extracellular deposit of amyloid-β in the form of senile plaques and intracellular neurofibrillary tangles (NFTs), which consist of pathological hyperphosphorylated tau protein aggregated into insoluble paired helical filaments (PHFs). Tau protein, a microtubule-associated protein, is abundant in neurons of the central nervous system. To keep nerves functioning properly, it stabilizes microtubules, which are important for supporting cell structure and cellular processes. When tau protein is modified, it stops functioning and a cell can’t maintain cell structure. Therefore hyperphosphorylated tau is believed to be a pathological hallmark of Alzheimer’s disease.
Heat shock protein 27(Hsp27), one of the sHsp (small heat shock protein) group, is known as a chaperone, which prevents protein aggregation and stabilizes denatured protein. Here we show that Hsp27 reduces hyperphosphorylated tau by helping its degradation. Moreover, Hsp27 rescues from hyperphosphorylated tau mediated cell death in neuroblastoma cell line SH-SY5Y.
Language
English
URI
http://hdl.handle.net/10371/134872
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College of Humanities (인문대학)Korean Language and Literature (국어국문학과)Others_국어국문학과
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