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Prevention of capsular contracture on silicone implants in rats using biomembrane-mimicking coatings

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Authors
함지연
Advisor
이연
Major
자연과학대학 화학부
Issue Date
2015-02
Publisher
서울대학교 대학원
Keywords
SiliconeCapsular contracturePhosphorylcholineSurface modificationForeign body reaction
Description
학위논문 (석사)-- 서울대학교 대학원 : 화학부, 2015. 2. 이연.
Abstract
Despite their popular use in breast augmentation and reconstruction surgeries, the limited biocompatibility of silicone implants can induce severe side effects, including capsular contracture – an excessive foreign body reaction that forms a tight and hard fibrous capsule around the implant. This study examines the effects of using biomembrane-mimicking surface coatings to prevent capsular formations on silicone implants. The covalently attached biomembrane-mimicking polymer, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), prevented nonspecific protein adsorption and fibroblast adhesion on the silicone surface. More importantly, in vivo capsule formations around PMPC-grafted silicone implants in rats were significantly thinner and exhibited lower collagen densities and more regular collagen alignments than bare silicone implants. The observed decrease in α-smooth muscle actin also supported the alleviation of capsular formations by the biomembrane-mimicking coating. Decreases in inflammation related cells, myeloperoxidase and transforming growth factor-β resulted in reduced inflammation in the capsular tissue. The biomembrane-mimicking coatings used on these silicone implants demonstrate great potential for preventing capsular contracture and developing biocompatible materials for various biomedical applications.
Language
English
URI
http://hdl.handle.net/10371/134917
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College of Humanities (인문대학)Korean Language and Literature (국어국문학과)Others_국어국문학과
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