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Prevention of capsular contracture on silicone implants in rats using biomembrane-mimicking coatings
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이연 | - |
dc.contributor.author | 함지연 | - |
dc.date.accessioned | 2017-07-27T02:19:41Z | - |
dc.date.available | 2017-07-27T02:19:41Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.other | 000000025679 | - |
dc.identifier.uri | https://hdl.handle.net/10371/134917 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 화학부, 2015. 2. 이연. | - |
dc.description.abstract | Despite their popular use in breast augmentation and reconstruction surgeries, the limited biocompatibility of silicone implants can induce severe side effects, including capsular contracture – an excessive foreign body reaction that forms a tight and hard fibrous capsule around the implant. This study examines the effects of using biomembrane-mimicking surface coatings to prevent capsular formations on silicone implants. The covalently attached biomembrane-mimicking polymer, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), prevented nonspecific protein adsorption and fibroblast adhesion on the silicone surface. More importantly, in vivo capsule formations around PMPC-grafted silicone implants in rats were significantly thinner and exhibited lower collagen densities and more regular collagen alignments than bare silicone implants. The observed decrease in α-smooth muscle actin also supported the alleviation of capsular formations by the biomembrane-mimicking coating. Decreases in inflammation related cells, myeloperoxidase and transforming growth factor-β resulted in reduced inflammation in the capsular tissue. The biomembrane-mimicking coatings used on these silicone implants demonstrate great potential for preventing capsular contracture and developing biocompatible materials for various biomedical applications. | - |
dc.description.tableofcontents | 1. Introduction
2. Materials and Methods 3. Results 4. Discussion 5. Conclusion 6. References 7. Figures ◈ 국문 초록 (Abstract in Korean) | - |
dc.format | application/pdf | - |
dc.format.extent | 1123151 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Silicone | - |
dc.subject | Capsular contracture | - |
dc.subject | Phosphorylcholine | - |
dc.subject | Surface modification | - |
dc.subject | Foreign body reaction | - |
dc.subject.ddc | 540 | - |
dc.title | Prevention of capsular contracture on silicone implants in rats using biomembrane-mimicking coatings | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.citation.pages | 42 | - |
dc.contributor.affiliation | 자연과학대학 화학부 | - |
dc.date.awarded | 2015-02 | - |
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