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Probes for Peroxynitrite Using Two-Photon Microscopy : 이광자 분광법을 이용한 과산화 아질산염에 대한 프로브
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 홍종인 | - |
dc.contributor.author | 박진희 | - |
dc.date.accessioned | 2017-07-27T02:20:16Z | - |
dc.date.available | 2017-07-27T02:20:16Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.other | 000000131117 | - |
dc.identifier.uri | https://hdl.handle.net/10371/134927 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 화학부 유기화학전공, 2016. 2. 홍종인. | - |
dc.description.abstract | Two-photon microscopy (TPM), utilizing two near-infrared (NIR) photons as the excitation source, has become a useful tool for biomedical research. However, only a few two-photon excitable probes for peroxynitrite have been developed that can detect peroxynitrite in various biological conditions using two-photon microscopy. However, two-photon peroxynitrite probe with an improved two-photon absorbing property is still required for further exploration.
Recently, it was reported that peroxynitrite can trigger oxidative N-dearylation reaction which can be used to induce fluorescence turn-on response. Thus, we have developed a new probe that can selectively detect peroxynitrite among other ROS/RNSs (Reactive oxygen/nitrogen species) utilizing dearylation reaction. The probe is highly selective and sensitive to peroxynitrite and has better two-photon excitation properties than any previous reported probes. Further, we synthesized two-photon excitable lanthanide complexes to introduce unique properties of lanthanide phosphorescence- Sharp, line-like emission bands with the same fingerprint wavelengths and narrow peak widths, and long excited-state lifetimes in the ms~μs range. With further modification, these lanthanide based two-photon probes can be used to discover the effects of peroxynitrite in biological systems which are not clearly understood. | - |
dc.description.tableofcontents | A. Back Ground 1
A.1. Two-Photon Probes 1 A.2. Lanthanide based probes 3 A.3. Luminescence probes for peroxynitrite 7 A.4. References 7 B. Two-Photon Probes for Peroxynitrite 10 B.1.Two-Photon turn-on probe for peroxynitrite 10 B.1.1. Introduction 10 B.1.2. Results and Discussion 11 B.1.3. Conclusion 24 B.1.4. Experimental Section 24 B.1.5. References 29 B.2.Lanthanide based Two-Photon probes for peroxynitrite 31 B.2.1. Introduction 31 B.2.2. Results and Discussion 32 B.2.3. Conclusion 35 B.2.4. Experimental Section 35 B.2.5. References 39 국문초록 40 | - |
dc.format | application/pdf | - |
dc.format.extent | 3580437 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Peroxynitrite | - |
dc.subject | Two-Photon Microscopy | - |
dc.subject | Fluorescence Probes | - |
dc.subject | Lanthanide complexes | - |
dc.subject.ddc | 540 | - |
dc.title | Probes for Peroxynitrite Using Two-Photon Microscopy | - |
dc.title.alternative | 이광자 분광법을 이용한 과산화 아질산염에 대한 프로브 | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.citation.pages | 44 | - |
dc.contributor.affiliation | 자연과학대학 화학부 | - |
dc.date.awarded | 2016-02 | - |
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