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Circulating sortilin level as a potential biomarker for coronary atherosclerosis and diabetes mellitus

Cited 10 time in Web of Science Cited 11 time in Scopus
Authors
Oh, Tae Jung; Ahn, Chang Ho; Kim, Bo-Rahm; Kim, Kyoung Min; Moon, Jae Hoon; Lim, Soo; Park, Kyong Soo; Lim, Cheong; Jang, HakChul; Choi, Sung Hee
Issue Date
2017-07-20
Publisher
BioMed Central
Citation
Cardiovascular Diabetology, 16(1):92
Keywords
Coronary artery diseaseDiabetes mellitusSortilinProneurotensinBiomarker
Description
ANOVA: analysis of variance; CABG: coronary artery bypass graft; CAD: coronary artery disease; LSD: least signifcant diference.
Abstract
Abstract

Context
A previous genome-wide association study showed that a genetic variant of sortilin was associated with the risk of coronary artery disease (CAD). However, the role of circulating sortilin is still unknown. We investigated the potential role of plasma sortilin as a biomarker for CAD and diabetes mellitus.

Methods
We enrolled statin-naïve subjects with CAD (n = 31) who underwent coronary artery bypass surgery and control subjects (n = 116) who were free from CAD as evaluated by coronary CT angiography. The presence of diabetes mellitus was evaluated and plasma sortilin levels were measured with a commercial ELISA kit.

Results
Plasma sortilin levels were higher in subjects with CAD and subjects with diabetes mellitus than in those without CAD or diabetes mellitus. Subjects in the highest sortilin tertile group were older and had higher glucose and HbA1c levels, but lipid profiles in the three tertile groups were comparable. Multivariable logistic regression analysis revealed that sortilin levels were independently associated with CAD. In addition, the receiver operating characteristic curve analysis showed that plasma sortilin levels could identify the presence of CAD or diabetes mellitus.

Conclusions
Elevated circulating sortilin levels are associated with CAD and diabetes mellitus and can be used as a biomarker of both diseases in statin-naïve subjects.
ISSN
1475-2840
Language
English
URI
http://hdl.handle.net/10371/138289
DOI
https://doi.org/10.1186/s12933-017-0568-9
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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