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Pathogenic genotype of major piroplasm surface protein associated with anemia in Theileria orientalis infection in cattle

Cited 6 time in Web of Science Cited 5 time in Scopus
Authors
Kim, Suhee; Yu, Do-Hyeon; Chae, Jeong-Byoung; Choi, Kyoung-Seong; Kim, Hyeon-Cheol; Park, Bae-Keun; Chae, Joon-Seok; Park, Jinho
Issue Date
2017-07-27
Publisher
BioMed Central
Citation
Acta Veterinaria Scandinavica, 59(1):51
Keywords
AnemiaMajor piroplasm surface proteinMPSP type 1Theileria orientalis
Description
Abbreviations
EDTA: ethylenediaminetetraacetic acid; Hb: hemoglobin; HCT: hematocrit; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; MCV: mean cell volume; MPSP: major piroplasm surface protein; PCR: polymerase chain reaction; RBC: red blood cell; rRNA: ribosomal RNA; T. orientalis: Theileria orientalis
Abstract
Abstract
Serious disease outbreaks in cattle caused by Theileria orientalis have emerged in the Asia–Pacific region. Genetic variables of the major piroplasm surface protein (MPSP) expressed on the surface of the piroplasm inside T. orientalis-infected erythrocytes are considered to be associated with variation in the pathogenicity of T. orientalis. Our study describes the clinically relevant MPSP types associated with anemia in Theileria-infected cattle. These results revealed that MPSP expression plays an important role in hematological alterations in Theileria-infected cattle, and that MPSP type 1 is strongly associated with bovine anemia, which can be a potential target for the prevention of bovine theileriosis.
ISSN
1751-0147
Language
English
URI
http://hdl.handle.net/10371/138307
DOI
https://doi.org/10.1186/s13028-017-0318-8
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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