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Ions doped melanin nanoparticle as a multiple imaging agent

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Authors
Ha, Shin-Woo; Cho, Hee-Sang; Yoon, Young Il; Jang, Moon-Sun; Hong, Kwan Soo; Hui, Emmanuel; Lee, Jung Hee; Yoon, Tae-Jong
Issue Date
2017-10-10
Publisher
BioMed Central
Citation
Journal of Nanobiotechnology, 15(1):73
Keywords
Melanin nanoparticleMRICTSPECTCancer imaging
Abstract
Abstract

Background
Multimodal nanomaterials are useful for providing enhanced diagnostic information simultaneously for a variety of in vivo imaging methods. According to our research findings, these multimodal nanomaterials offer promising applications for cancer therapy.

Results
Melanin nanoparticles can be used as a platform imaging material and they can be simply produced by complexation with various imaging active ions. They are capable of specifically targeting epidermal growth factor receptor (EGFR)-expressing cancer cells by being anchored with a specific antibody. Ion-doped melanin nanoparticles were found to have high bioavailability with long-term stability in solution, without any cytotoxicity in both in vitro and in vivo systems.

Conclusion
By combining different imaging modalities with melanin particles, we can use the complexes to obtain faster diagnoses by computed tomography deep-body imaging and greater detailed pathological diagnostic information by magnetic resonance imaging. The ion-doped melanin nanoparticles also have applications for radio-diagnostic treatment and radio imaging-guided surgery, warranting further proof of concept experimental.
ISSN
1477-3155
Language
English
URI
http://hdl.handle.net/10371/138332
DOI
https://doi.org/10.1186/s12951-017-0304-3
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College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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