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Ions doped melanin nanoparticle as a multiple imaging agent
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ha, Shin-Woo | - |
dc.contributor.author | Cho, Hee-Sang | - |
dc.contributor.author | Yoon, Young Il | - |
dc.contributor.author | Jang, Moon-Sun | - |
dc.contributor.author | Hong, Kwan Soo | - |
dc.contributor.author | Hui, Emmanuel | - |
dc.contributor.author | Lee, Jung Hee | - |
dc.contributor.author | Yoon, Tae-Jong | - |
dc.date.accessioned | 2017-11-03T06:03:32Z | - |
dc.date.available | 2017-11-03T15:04:16Z | - |
dc.date.issued | 2017-10-10 | - |
dc.identifier.citation | Journal of Nanobiotechnology, 15(1):73 | ko_KR |
dc.identifier.issn | 1477-3155 | - |
dc.identifier.uri | https://hdl.handle.net/10371/138332 | - |
dc.description.abstract | Abstract
Background Multimodal nanomaterials are useful for providing enhanced diagnostic information simultaneously for a variety of in vivo imaging methods. According to our research findings, these multimodal nanomaterials offer promising applications for cancer therapy. Results Melanin nanoparticles can be used as a platform imaging material and they can be simply produced by complexation with various imaging active ions. They are capable of specifically targeting epidermal growth factor receptor (EGFR)-expressing cancer cells by being anchored with a specific antibody. Ion-doped melanin nanoparticles were found to have high bioavailability with long-term stability in solution, without any cytotoxicity in both in vitro and in vivo systems. Conclusion By combining different imaging modalities with melanin particles, we can use the complexes to obtain faster diagnoses by computed tomography deep-body imaging and greater detailed pathological diagnostic information by magnetic resonance imaging. The ion-doped melanin nanoparticles also have applications for radio-diagnostic treatment and radio imaging-guided surgery, warranting further proof of concept experimental. | ko_KR |
dc.description.sponsorship | This work was supported by the Industrial Technology Development Program (Project No. 10047679) funded by the Ministry of Trade, Industry & Energy (MI, Korea) and the GRRC program of Gyeonggi province (GRRC 2016B02, Photonics-Medical Convergence Technology Research Center). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Melanin nanoparticle | ko_KR |
dc.subject | MRI | ko_KR |
dc.subject | CT | ko_KR |
dc.subject | SPECT | ko_KR |
dc.subject | Cancer imaging | ko_KR |
dc.title | Ions doped melanin nanoparticle as a multiple imaging agent | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 하신우 | - |
dc.contributor.AlternativeAuthor | 조희상 | - |
dc.contributor.AlternativeAuthor | 윤영일 | - |
dc.contributor.AlternativeAuthor | 장문선 | - |
dc.contributor.AlternativeAuthor | 홍관수 | - |
dc.contributor.AlternativeAuthor | 이정희 | - |
dc.contributor.AlternativeAuthor | 윤태종 | - |
dc.identifier.doi | 10.1186/s12951-017-0304-3 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2017-10-16T07:08:11Z | - |
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