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Transglycosylation of gallic acid by using Leuconostoc glucansucrase and its characterization as a functional cosmetic agent
Cited 17 time in
Web of Science
Cited 19 time in Scopus
- Authors
- Issue Date
- 2017-12-22
- Publisher
- Springer Open
- Citation
- AMB Express, 22;7(1):224
- Keywords
- Leuconostoc mesenteroides ; Dextransucrase ; Gallic acid ; Glucosylation ; Whitening efect ; Anti-aging efect
- Abstract
- Abstract
Gallic acid glycoside was enzymatically synthesized by using dextransucrase and sucrose from gallic acid. After purification by butanol partitioning and preparative HPLC, gallic acid glucoside was detected at m/z 355 (C13, H16, O10, Na)+ by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The yield of gallic acid glucoside was found to be 35.7% (114mM) by response surface methodology using a reaction mixture of 319mM gallic acid, 355mM sucrose, and 930mU/mL dextransucrase. The gallic acid glucoside obtained showed 31% higher anti-lipid peroxidation and stronger inhibition (Ki=1.23mM) against tyrosinase than that shown by gallic acid (Ki=1.98mM). In UVB-irradiated human fibroblast cells, gallic acid glucoside lowered matrix metalloproteinase-1 levels and increased the collagen content, which was indicative of a stronger anti-aging effect than that of gallic acid or arbutin. These results indicated that gallic acid glucoside is likely a superior cosmetic ingredient with skin-whitening and anti-aging functions.
- ISSN
- 2191-0855
- Language
- English
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