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Clinicopathological factors influencing the outcomes of surgical treatment in patients with T4a hypopharyngeal cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sang-Yeon | - |
dc.contributor.author | Rho, Young-Soo | - |
dc.contributor.author | Choi, Eun-Chang | - |
dc.contributor.author | Kim, Min-Sik | - |
dc.contributor.author | Woo, Joo-Hyun | - |
dc.contributor.author | Lee, Dong Hoon | - |
dc.contributor.author | Chung, Eun Jae | - |
dc.contributor.author | Park, Min Woo | - |
dc.contributor.author | Kim, Da-Hee | - |
dc.contributor.author | Joo, Young-Hoon | - |
dc.date.accessioned | 2018-01-12T05:25:36Z | - |
dc.date.available | 2018-01-12T14:26:33Z | - |
dc.date.issued | 2017-12-29 | - |
dc.identifier.citation | BMC Cancer, 17(1):904 | ko_KR |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://hdl.handle.net/10371/138476 | - |
dc.description.abstract | Background
The purpose of this study was to determine prognostic factors influencing outcomes of surgical treatment in patients with T4a hypopharyngeal cancer. Methods The present study enrolled 93 patients diagnosed with T4a hypopharyngeal cancer who underwent primary surgery between January 2005 and December 2015 at six medical centers in Korea. Primary tumor sites included pyriform sinus in 71 patients, posterior pharyngeal wall in 14 patients, and postcricoid region in 8 patients. Seventy-two patients received postoperative radio(chemo)therapy. Results Five-year disease-free survival (DFS) and disease-specific survival (DSS) rates were 38% and 45%, respectively. In univariate analysis, 5-year DFS was found to have significant and positive correlations with margin involvement (p < 0.001) and extracapsular spread (p = 0.025). Multivariate analysis confirmed that margin involvement (hazard ratio (HR): 2.81; 95% confidence interval (CI): 1.49-5.30; p = 0.001) and extracapsular spread (HR: 2.08; 95% CI: 1.08-3.99; p = 0.028) were significant factors associated with 5-year DFS. In univariate analysis, cervical lymph node metastasis (p = 0.048), lymphovascular invasion (p = 0.041), extracapsular spread (p = 0.015), and esophageal invasion (p = 0.033) were significant factors associated with 5-year DSS. In multivariate analysis, extracapsular spread (HR: 2.98; 95% CI: 1.39-6.42; p = 0.005) and esophageal invasion (HR: 2.87; 95% CI: 1.38-5.98; p = 0.005) remained significant factors associated with 5-year DSS. Conclusion Margin involvement and extracapsular spread are factors influencing recurrence while extracapsular spread and esophageal invasion are factors affecting survival in patients with T4a hypopharyngeal cancer treated by primary surgery. | ko_KR |
dc.description.sponsorship | This study was supported by the Research Committee of Korean Society of Thyroid Head and Neck Surgery. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Head and neck neoplasms | ko_KR |
dc.subject | Hypopharynx | ko_KR |
dc.subject | Squamous cell carcinoma | ko_KR |
dc.subject | Surgery | ko_KR |
dc.subject | Treatment outcome | ko_KR |
dc.title | Clinicopathological factors influencing the outcomes of surgical treatment in patients with T4a hypopharyngeal cancer | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김상연 | - |
dc.contributor.AlternativeAuthor | 노영수 | - |
dc.contributor.AlternativeAuthor | 최은창 | - |
dc.contributor.AlternativeAuthor | 김민식 | - |
dc.contributor.AlternativeAuthor | 우주현 | - |
dc.contributor.AlternativeAuthor | 이동훈 | - |
dc.contributor.AlternativeAuthor | 정은재 | - |
dc.contributor.AlternativeAuthor | 박민우 | - |
dc.contributor.AlternativeAuthor | 김다희 | - |
dc.identifier.doi | 10.1186/s12885-017-3880-6 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2017-12-31T04:19:59Z | - |
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