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Control of the gastrointestinal digestion of solid lipid nanoparticles using PEGylated emulsifiers

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Authors
Ban, Choongjin; Jo, Myeongsu; Lim, Seokwon; Choi, Young Jin
Issue Date
2018-01
Publisher
ELSEVIER SCI LTD
Citation
Food Chemistry, Vol.239, pp. 442-452
Keywords
Control of the gastrointestinal digestion of solid lipid nanoparticles using PEGylated emulsifiers자연과학Solid lipid nanoparticlePolyethylene glycolOral administrationGastrointestinal digestionControllable digestion
Abstract
We prepared solid lipid nanoparticles (SLNs) with tristearin and various emulsifiers which had different chain length PEGs (10-100 times-repetition of ethylene glycol) to control their digestion fate in the gastrointestinal tract. Fabricated SLNs after acidic/high-ionic-strength media treatment were stable regardless of the f-potential (ZP) disappearance. Additionally, highly PEGylated SLNs successfully hindered the adsorption of both bile acid (BA) and lipase on the SLN surface, while lowly PEGylated SLNs interrupted that of only lipase. In simulated small intestinal fluid, lipolysis of highly PEGylated SLNs increased with decrease of the emulsifier density on the SLNs, whereas lipolysis of lowly PEGylated SLNs increased with decrease of the particle size. These results suggested that high PEGylation was more efficient than low PEGylation to hinder the lipolysis initiated from the competitive replacement of the SLN-covering emulsifiers with BAs. Consequently, the SLN digestion could be controlled by choosing the length and concentration of PEGylated emulsifiers. (C) 2017 Elsevier Ltd. All rights reserved.
ISSN
0308-8146
Language
English
URI
http://hdl.handle.net/10371/139294
DOI
https://doi.org/10.1016/j.foodchem.2017.06.137
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Agricultural Biotechnology (농생명공학부)Journal Papers (저널논문_농생명공학부)
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