Publications
Detailed Information
Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ho Jin | - |
dc.contributor.author | Pham, Phuong Chi | - |
dc.contributor.author | Hyun, Seung Yeob | - |
dc.contributor.author | Baek, Byungyeob | - |
dc.contributor.author | Kim, Byungjin | - |
dc.contributor.author | Kim, Yunha | - |
dc.contributor.author | Min, Hye-Young | - |
dc.contributor.author | Lee, Jeeyeon | - |
dc.contributor.author | Lee, Ho-Young | - |
dc.date.accessioned | 2018-03-19T00:24:54Z | - |
dc.date.available | 2018-03-19T09:25:46Z | - |
dc.date.issued | 2018-02-19 | - |
dc.identifier.citation | Molecular Cancer, 17(1):50 | ko_KR |
dc.identifier.issn | 1476-4598 | - |
dc.identifier.uri | https://hdl.handle.net/10371/139617 | - |
dc.description.abstract | Background
Both the type I insulin-like growth factor receptor (IGF1R) and Src pathways are associated with the development and progression of numerous types of human cancer, and Src activation confers resistance to anti-IGF1R therapies. Hence, targeting both IGF1R and Src concurrently is one of the main challenges in combating resistance to the currently available anti-IGF1R-based anticancer therapies. However, the enhanced toxicity from this combinatorial treatment could be one of the main hurdles for this strategy, suggesting the necessity of developing a novel strategy for co-targeting IGF1R and Src to meet an urgent clinical need. Methods We synthesized a series of 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitors, selected LL28 as an active compound and evaluated its potential antitumor effects in vitro and in vivo using the MTT assay, colony formation assays, flow cytometric analysis, a tumor xenograft model, and the Kras G12D/+ -driven spontaneous lung tumorigenesis model. Results LL28 markedly suppressed the activation of IGF1R and Src and significantly inhibited the viability of several NSCLC cell lines in vitro by inducing apoptosis. Administration of mice with LL28 significantly suppressed the growth of H1299 NSCLC xenograft tumors without overt toxicity and substantially reduced the multiplicity, volume, and load of lung tumors in the Kras G12D/+ -driven lung tumorigenesis model. Conclusions The present results suggest the potential of LL28 as a novel anticancer drug candidate targeting both IGF1R and Src, providing a new avenue to efficient anticancer therapies. Further investigation is warranted in advanced preclinical and clinical settings. | ko_KR |
dc.description.sponsorship | This work was supported by grants from the National Research Foundation of Korea (NRF), the Ministry of Science and ICT (MSIT), Republic of Korea (No. NRF-2016R1A3B1908631 to H. Y. Lee; NRF-2015R1A2A2A01007646 to J. Lee). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.title | Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이호진 | - |
dc.contributor.AlternativeAuthor | 현승엽 | - |
dc.contributor.AlternativeAuthor | 백병엽 | - |
dc.contributor.AlternativeAuthor | 김병진 | - |
dc.contributor.AlternativeAuthor | 김윤하 | - |
dc.contributor.AlternativeAuthor | 민혜영 | - |
dc.contributor.AlternativeAuthor | 이지연 | - |
dc.contributor.AlternativeAuthor | 이호영 | - |
dc.identifier.doi | 10.1186/s12943-018-0802-4 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2018-02-25T04:18:14Z | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.