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The attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, Jung-Hee | - |
dc.contributor.author | Park, Jin-woo | - |
dc.contributor.author | Hwang, Jin-Young | - |
dc.contributor.author | Park, Seong-Joo | - |
dc.contributor.author | Kim, Jin-Hee | - |
dc.contributor.author | Sohn, Hye-Min | - |
dc.contributor.author | Han, Sung Hee | - |
dc.date.accessioned | 2018-05-15T02:18:34Z | - |
dc.date.available | 2018-05-15T11:19:39Z | - |
dc.date.issued | 2018-03-27 | - |
dc.identifier.citation | BMC Anesthesiology, 18(1):31 | ko_KR |
dc.identifier.issn | 1471-2253 | - |
dc.identifier.uri | https://hdl.handle.net/10371/139761 | - |
dc.description.abstract | Background
Spinal cord ischemic injury remains a serious complication of open surgical and endovascular aortic procedures. Simvastatin has been reported to be associated with neuroprotective effect after spinal cord ischemia-reperfusion (IR) injury. The aim of this study was to determine the therapeutic efficacy of starting simvastatin after spinal cord IR injury in a rat model. Methods In adult Sprague-Dawley rats, spinal cord ischemia was induced using a balloon-tipped catheter placed in the descending thoracic aorta. The animals were then randomly divided into 4 groups: group A (control); group B (0.5mg/kg simvastatin); group C (1mg/kg simvastatin); and group D (10mg/kg simvastatin). Simvastatin was administered orally upon reperfusion for 5days. Neurological function of the hind limbs was evaluated for 7days after reperfusion and recorded using a motor deficit score (MDS) (0: normal, 5: complete paraplegia). The number of normal motor neurons within the anterior horns of the spinal cord was counted after final MDS evaluation. Then, the spinal cord was harvested for histopathological examination. Results Group D showed a significantly lower MDS than the other groups at post-reperfusion day 1 and this trend was sustained throughout the study period. Additionally, a greater number of normal motor neurons was observed in group D than in other groups (group D 21.2 [3.2] vs. group A: 15.8 [4.2]; group B 15.4 [3.4]; and group C 15.5 [3.7]; P = 0.002). Conclusions The results of the current study suggest that 10mg/kg can significantly improve neurologic outcome by attenuating neurologic injury and restoring normal motor neurons after spinal cord IR injury. | ko_KR |
dc.description.sponsorship | This study was supported by the Seoul National University Bundang Hospital research fund (042011006 to S.H Han). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Neuroprotection | ko_KR |
dc.subject | Simvastatin | ko_KR |
dc.subject | Reperfusion injury | ko_KR |
dc.subject | Thoracoabdominal aortic surgery | ko_KR |
dc.title | The attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 류정희 | - |
dc.contributor.AlternativeAuthor | 박진우 | - |
dc.contributor.AlternativeAuthor | 황진영 | - |
dc.contributor.AlternativeAuthor | 박성주 | - |
dc.contributor.AlternativeAuthor | 김진희 | - |
dc.contributor.AlternativeAuthor | 손혜민 | - |
dc.contributor.AlternativeAuthor | 한성희 | - |
dc.identifier.doi | 10.1186/s12871-018-0496-6 | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2018-04-01T13:25:20Z | - |
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