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Effect of an intervention targeting inappropriate continued empirical parenteral vancomycin use: a quasi-experimental study in a region of high MRSA prevalence
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Koo, Hei Lim | - |
dc.contributor.author | Yoon, Doran | - |
dc.contributor.author | Bae, Ji Yun | - |
dc.contributor.author | Lee, Eunyoung | - |
dc.contributor.author | Hwang, Joo-Hee | - |
dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Bang, Ji Hwan | - |
dc.contributor.author | Kim, Eu Suk | - |
dc.contributor.author | Kim, Hong Bin | - |
dc.contributor.author | Park, Sang Won | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.contributor.author | Kim, Nam Joong | - |
dc.date.accessioned | 2018-05-29T01:22:02Z | - |
dc.date.available | 2018-05-29T10:22:47Z | - |
dc.date.issued | 2018-04-16 | - |
dc.identifier.citation | BMC Infectious Diseases, 18(1):178 | ko_KR |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | https://hdl.handle.net/10371/141240 | - |
dc.description.abstract | Background
Despite vancomycin use is a major risk factor for the emergence of vancomycin resistance, it is frequently inappropriately prescribed, especially as empirical treatment. We evaluated the effect of an antimicrobial stewardship intervention targeting for inappropriate continued empirical vancomycin use. Methods This was a quasi-experimental study comparing vancomycin use in a 6-month pre-intervention and 6-month intervention period. If empirical vancomycin was continued for more than 96h without documentation of beta-lactam-resistant gram-positive microorganisms, it was considered inappropriate continued empirical vancomycin use. The intervention consisted of the monitoring of appropriateness by a pharmacist and direct discussion with the prescribing physicians by infectious disease specialists when empirical vancomycin was continued inappropriately. An interrupted time series analysis was used to compare vancomycin use before and during the intervention. Results Following implementation of the intervention, overall vancomycin consumption decreased by 14.6%, from 37.6 defined daily doses (DDDs)/1000 patient-days in the pre-intervention period to 32.1 DDDs/1000 patient-days in the intervention period (P < 0.001). The inappropriate consumption of vancomycin also declined from 8.0 DDDs/1000 patient-days to 5.8 DDDs/1000 patient-days (P = 0.009). Conclusion Interventions such as direct communication with prescribing physicians and infectious disease clinicians can help reduce the inappropriate continued use of vancomycin. | ko_KR |
dc.description.sponsorship | This study was supported by a research grant from Seoul National University Hospital (Grant No. 2013–2425). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Vancomycin | ko_KR |
dc.subject | Inappropriate use | ko_KR |
dc.subject | Antimicrobial stewardship | ko_KR |
dc.subject | Intervention | ko_KR |
dc.subject | Pharmacist | ko_KR |
dc.subject | Infectious disease specialist | ko_KR |
dc.title | Effect of an intervention targeting inappropriate continued empirical parenteral vancomycin use: a quasi-experimental study in a region of high MRSA prevalence | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 채평균 | - |
dc.contributor.AlternativeAuthor | 구혜림 | - |
dc.contributor.AlternativeAuthor | 윤도란 | - |
dc.contributor.AlternativeAuthor | 배지윤 | - |
dc.contributor.AlternativeAuthor | 이은영 | - |
dc.contributor.AlternativeAuthor | 황주희 | - |
dc.contributor.AlternativeAuthor | 송경호 | - |
dc.contributor.AlternativeAuthor | 박완범 | - |
dc.contributor.AlternativeAuthor | 김유숙 | - |
dc.contributor.AlternativeAuthor | 김홍빈 | - |
dc.contributor.AlternativeAuthor | 박상원 | - |
dc.contributor.AlternativeAuthor | 오명돈 | - |
dc.contributor.AlternativeAuthor | 김남중 | - |
dc.identifier.doi | 10.1186/s12879-018-3081-1 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2018-04-22T03:31:31Z | - |
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