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Artificial homeostasis regulation system consisting of wearable bio-sensing electrodes and wirelessly interconnected microneedle patch : 착용할 수 있는 생체 감지 전극과 무선으로 연결된 마이크로 바늘 패치로 구성된 인공적인 항상성 조절 시스템
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- Authors
- Advisor
- 김대형
- Major
- 공과대학 화학생물공학부
- Issue Date
- 2018-02
- Publisher
- 서울대학교 대학원
- Keywords
- bio-inspired endocrine system ; homeostasis regulation ; electrochemical sensors ; DET electrode ; microneedle drug delivery ; preventive medicine
- Description
- 학위논문 (석사)-- 서울대학교 대학원 : 공과대학 화학생물공학부, 2018. 2. 김대형.
- Abstract
- Homeostasis state regulation is the major role of human nerve and endocrine systems. Several factors such as blood glucose, cortisol hormone levels, electrolyte levels, and body temperature are detected and controlled by these systems. However, failure of human endocrine system causes many chronic diseases such as diabetes, depression, and high fever. Here, bio-inspired wireless platform integrated with wearable biosensor, smartphone networking, and wearable microneedle patch was proposed for artificial homeostasis regulation. Direct electron transfer (DET) electrode have been developed for wearable biosensor using vertically aligned carbon nanotube (VACNT)-graphene (GP)-Au mesh structure for accurate biomarker detection from sweat. In addition, the drug-loaded microneedle is attached with wearable heater patch, enabling transdermal drug delivery with the sensor detection for closed-loop feedback. Finally, all these components are controlled by user-friendly smartphone application that mimic the human nerve system. Artificial regulation platform of human homeostasis provides a helpful tool for preventing chronic disease.
- Language
- English
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