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Chemical Constituents from Cudrania tricuspidata
꾸지뽕나무의 화학 성분

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Authors
최영헌
Advisor
김진웅
Major
약학대학 약학과
Issue Date
2018-02
Publisher
서울대학교 대학원
Keywords
Cudrania tricupidataMoraceaeflavonoid
Description
학위논문 (석사)-- 서울대학교 대학원 : 약학대학 약학과, 2018. 2. 김진웅.
Abstract
Cudrania tricuspidata Bureau, belonging to Moraceae family, is mainly distributed in Korea, Japan and China. Leaves of C. tricuspidata have been used for eczema, mumps, tuberculosis as a traditional medicine. Phytochemical studies revealed that major constituents of this plant are various types of flavonoids xanthones.
The leaves and twigs of C. tricuspidata were extracted with 100% methanol. The extract was suspended in H2O and the subsequently fractionated with n-hexane, CHCl3, EtOAc and n-BuOH. Thirty compounds were isolated from EtOAC, n-BuOH by various chromatographic techniques. Structure of compounds was elucidated based on NMR, MASS and FT-IR spectroscopic data. Compounds were identified as 4ꞌ-glucopyranosyloxybenzyl-4-O-β-D-glucopyranosyloxy-3,5-dimethoxybenzoate (1), Bis [4-O-β-D-glucopyranosyloxy)benzyl] 3-hydroxy-3-methylglutarate (2), Gastrodin (3), p-hydroxybenzaldehyde-4-O-β-D-glucopyranoside (4), 3,4,5-trimethoxy phenyl-1-O-β-D-glucopyranoside (5), Cudrabibenzyl A (6), (6S, 9R)-Roseoside (7), 3-O-caffeoyl-2-C-methyl-D-erythrono-1,4-lactone (8), Chlorogenic acid (9) Umbelliferone (10), Skimmin (11), Esculin (12), C-veratroylglycol (13), 2,3-dihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)propan-1-one (14), 4-hydroxy benzoic acid (15), Methyl-4-hydroxy benzoate (16), Quercetin (17), Quercetin-3-O-β-D-glucopyranoside (18), Quercetin-7-O-β-D-glucopyranoside (19), Kaempferol-7-O-β-D-glucopyranoside (20), Nicotiflorin (21), Aromadendrin (22), Aromadendrin-7-O-β-D-glucopyranoside (23), Gericudranin E (24), Taxifolin (25), Dihydromorin (26), Orobol (27), Orobol-7-O-β-D-glucopyranoside (28), Ambocin (29), 5-methoxy-8-glucopyranosyl-genistein (30). Compounds 1-5 were phenolic type, compound 6 was stilbenoid type, compound 7 was megastigmane derivative, compounds 8-9 were caffeoyl derivatives, compounds 10-12 were coumarin type, compounds 13-14 were phenylpropanoid type, compounds 15-16 were benzoic acid derivatives, compounds 17-30 were flavonoid type. Among them, compounds 1 and 2 were newly reported in nature. Compounds 3, 4, 5, 13, 14, 15, 16, 29 were newly reported from Moraceae family. Compounds 7, 11, 12 were newly reported from Cudrania genus.
Language
English
URI
http://hdl.handle.net/10371/142217
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Theses (Master's Degree_약학과)
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