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Chemical Constituents from Cudrania tricuspidata : 꾸지뽕나무의 화학 성분
DC Field | Value | Language |
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dc.contributor.advisor | 김진웅 | - |
dc.contributor.author | 최영헌 | - |
dc.date.accessioned | 2018-05-29T04:41:56Z | - |
dc.date.available | 2018-05-29T04:41:56Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.other | 000000150109 | - |
dc.identifier.uri | https://hdl.handle.net/10371/142217 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 약학대학 약학과, 2018. 2. 김진웅. | - |
dc.description.abstract | Cudrania tricuspidata Bureau, belonging to Moraceae family, is mainly distributed in Korea, Japan and China. Leaves of C. tricuspidata have been used for eczema, mumps, tuberculosis as a traditional medicine. Phytochemical studies revealed that major constituents of this plant are various types of flavonoids xanthones.
The leaves and twigs of C. tricuspidata were extracted with 100% methanol. The extract was suspended in H2O and the subsequently fractionated with n-hexane, CHCl3, EtOAc and n-BuOH. Thirty compounds were isolated from EtOAC, n-BuOH by various chromatographic techniques. Structure of compounds was elucidated based on NMR, MASS and FT-IR spectroscopic data. Compounds were identified as 4ꞌ-glucopyranosyloxybenzyl-4-O-β-D-glucopyranosyloxy-3,5-dimethoxybenzoate (1), Bis [4-O-β-D-glucopyranosyloxy)benzyl] 3-hydroxy-3-methylglutarate (2), Gastrodin (3), p-hydroxybenzaldehyde-4-O-β-D-glucopyranoside (4), 3,4,5-trimethoxy phenyl-1-O-β-D-glucopyranoside (5), Cudrabibenzyl A (6), (6S, 9R)-Roseoside (7), 3-O-caffeoyl-2-C-methyl-D-erythrono-1,4-lactone (8), Chlorogenic acid (9) Umbelliferone (10), Skimmin (11), Esculin (12), C-veratroylglycol (13), 2,3-dihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)propan-1-one (14), 4-hydroxy benzoic acid (15), Methyl-4-hydroxy benzoate (16), Quercetin (17), Quercetin-3-O-β-D-glucopyranoside (18), Quercetin-7-O-β-D-glucopyranoside (19), Kaempferol-7-O-β-D-glucopyranoside (20), Nicotiflorin (21), Aromadendrin (22), Aromadendrin-7-O-β-D-glucopyranoside (23), Gericudranin E (24), Taxifolin (25), Dihydromorin (26), Orobol (27), Orobol-7-O-β-D-glucopyranoside (28), Ambocin (29), 5-methoxy-8-glucopyranosyl-genistein (30). Compounds 1-5 were phenolic type, compound 6 was stilbenoid type, compound 7 was megastigmane derivative, compounds 8-9 were caffeoyl derivatives, compounds 10-12 were coumarin type, compounds 13-14 were phenylpropanoid type, compounds 15-16 were benzoic acid derivatives, compounds 17-30 were flavonoid type. Among them, compounds 1 and 2 were newly reported in nature. Compounds 3, 4, 5, 13, 14, 15, 16, 29 were newly reported from Moraceae family. Compounds 7, 11, 12 were newly reported from Cudrania genus. | - |
dc.description.tableofcontents | Chapter1. Introduction 1
Chapter2. Experimental Section 3 2.1. Material 3 2.1.1. Plant material 3 2.1.2. Reagents 3 2.1.3. Equipments 3 2.2. Method 5 2.3. Spectroscopic and spectrometric data of isolated compounds 14 4'-glucopyranosyloxybenzyl-4-O-β-D-glucopyranosyloxy 3,5 dimethoxybenzoate (1) 14 Bis [4-O-β-D-glucopyranosyloxy)benzyl] 3-hydroxy-3-methyl glutarate (2) 14 Gastrodin (3) 18 p-hydroxybenzaldehyde 4-O-β-D-glucopyranoside (4) 18 3,4,5-trimethoxyphenyl-1-O-β-D-glucopyranoside (5) 20 Cudrabibenzyl A (6) 20 (6S, 9R) Roseoside (7) 23 3-O-caffeoyl-2-C-methyl-D-erythrono-1,4-lactone (8) 25 Chlorogenic acid (9) 25 Umbelliferone (10) 27 Skimmin (11) 27 Esculin (12) 27 C-veratroylglycol (13) 29 2,3-dihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-propanone (14) 29 4-hydroxy benzoic acid (15) 30 Methyl-4-hydroxy benzoate (16) 30 Quercetin (17) 32 Quercetin-3-O-β-D-glucopyranoside (18) 32 Quercetin-7-O-β-D-glucopyranoside (19) 32 Kaempferol-7-O-β-D-glucopyranoside (20) 33 Nicotiflorin (21) 33 Aromadendrin (22) 36 Aromadendrin-7-O-β-D-glucopyranoside (23) 36 Gericudranin E (24) 36 Taxifolin (25) 37 Dihydromorin (26) 37 Orobol (27) 41 Orobol-7-O-β-D-glucopyranoside (28) 41 Ambocin (29) 41 5-methoxy-8-glucopyranosyl-genistein (30) 42 Chapter3. Results and Discussion 45 3.1. Compound 1 45 3.2. Compound 2 51 3.3. Compound 3 56 3.4. Compound 4 59 3.5. Compound 5 62 3.6. Compound 6 65 3.7. Compound 7 68 3.8. Compound 8 71 3.9. Compound 9 74 3.10. Compounds 10-11 77 3.11. Compound 12 82 3.12. Compound 13 85 3.13. Compound 14 88 3.14. Compounds 15-16 91 3.15. Compounds 17-19 96 3.16. Compound 20 103 3.17. Compound 21 106 3.18. Compounds 22-24 109 3.19. Compound 25 116 3.20. Compound 26 119 3.21. Compounds 27-28 122 3.22. Compound 29 127 3.23. Compound 30 130 Chapter4. Conclusion 133 Reference 134 Supplementary Information 141 국문초록 150 | - |
dc.format | application/pdf | - |
dc.format.extent | 3044091 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Cudrania tricupidata | - |
dc.subject | Moraceae | - |
dc.subject | flavonoid | - |
dc.subject.ddc | 615 | - |
dc.title | Chemical Constituents from Cudrania tricuspidata | - |
dc.title.alternative | 꾸지뽕나무의 화학 성분 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Choi Young heon | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 약학대학 약학과 | - |
dc.date.awarded | 2018-02 | - |
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