Publications
Detailed Information
Higher rate of Epstein-Barr virus incorporation on decidualendometrial cells in pregnant women with preeclampsia
Cited 0 time in
Web of Science
Cited 0 time in Scopus
- Authors
- Advisor
- 박중신
- Major
- 의과대학 의학과
- Issue Date
- 2018-02
- Publisher
- 서울대학교 대학원
- Keywords
- Preeclampsia ; Epstein-Barr virus ; in situ hybridization ; virus latency ; endometrial
- Description
- 학위논문 (석사)-- 서울대학교 대학원 : 의과대학 의학과, 2018. 2. 박중신.
- Abstract
- Introduction: There are various theories regarding the pathogenesis and pathophysiology of preeclampsia, but the exact cause of preeclampsia is not yet clearly established. Previous investigators have suggested that preeclampsia may be associated with Epstein-Barr virus (EBV) infection in the B lymphocytes during pregnancy based on polymerase chain reaction or serological tests. The purpose of this study was to evaluate the prevalence of EBV-positivity in women diagnosed with and without preeclampsia using placental specimens.
Materials and methods:This retrospective study included 85 pregnant women with preeclampsia and 65 pregnant women without preeclampsia. Placental specimens were assessed for the presence of acute and chronic inflammation. EBV-positivity was evaluated using in situ hybridization on EBV genes from tissue microarray slides. Clinicopathological characteristics were compared between women with and without preeclampsia and between EBV-positive and EBV-negative women.
Results: Women with preeclampsia showed a higher occurrence of EBV-positive cells than those without preeclampsia (36.5% vs 20.0%, p = 0.028). When stratified into gestational age, the occurrence of EBV-positivecells were consistently higher in women with preeclampsia with preterm delivery (39.1% vs 20.0%, p = 0.042) but not in those with full-term (28.6% vs 20.0%, p = 0.497).
Conclusion: We found increased EBV infected placenta of women with preeclampsia compared with those without preeclamplasia. Further study is needed to elucidate the etiological role of EBV infection during development of preeclampsia.
- Language
- English
- Files in This Item:
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.