SHERP

일차성 아밀로이드증의 혈전 발생빈도 및 위험 인자
The incidence and risk factors for thromboembolism in AL amyloidosis

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Authors
박현경
Advisor
윤성수
Major
의과대학 의학과
Issue Date
2018
Publisher
서울대학교 대학원
Keywords
amyloidosisplasma cell dyscrasiathromboembolismlight chainbeta 2-microglobulin
Description
학위논문 (석사)-- 서울대학교 대학원 : 의과대학 의학과, 2018. 2. 윤성수.
Abstract
Background: AL amyloidosis may increase the risk for thromboembolism as well as other plasma cell dyscrasias
however, only a few reports have described the clinical features of thromboembolism. This study aimed to elucidate the clinical features of thromboembolic events and to identify risk factors for these events.
Methods: Medical records were retrospectively reviewed to define clinically significant thromboembolic events.
Results: A total of 106 patients with biopsy-proven AL amyloidosis were included. During a median follow-up of 18.1 months (range, 0.4–166.9 months), 13 thromboembolism events were identified in 13 patients: 9 patients (8.5%) experienced acute cerebral infarction, 2 patients (1.9%) experienced pulmonary embolism, and 2 patients (1.9%) experienced deep vein thrombosis. Patients with higher serum free light chain (FLC) difference (≥375.2 mg/L) or beta-2 microglobulin (B2MG) levels (≥2.94 mg/L) experienced significantly more thromboembolic events than those with lower value according to multivariable analysis (hazard ratio [HR], 3.537 [95% CI, 1.051–11.898], P=0.041 for FLC difference
HR, 19.185 [95% CI, 1.848–199.195], P=0.013 for B2MG). Most thromboembolic events (11/13, 84.6%) occurred within the first year following AL amyloidosis diagnosis.
Conclusions: The incidence of thromboembolism was substantial in AL amyloidosis. Higher FLC difference and B2MG levels were risk factors for thromboembolic events.
Language
Korean
URI
http://hdl.handle.net/10371/142357
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Theses (Master's Degree_의학과)
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