S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Clinical Medical Sciences (임상의과학과) Theses (Master's Degree_임상의과학과)
Role of serum activin-A in ARDS patients
급성호흡곤란증후군 환자에서 혈청 activin-A가 갖는 임상적 의미
- 의과대학 임상의과학과
- Issue Date
- 서울대학교 대학원
- 학위논문 (석사)-- 서울대학교 대학원 : 의과대학 임상의과학과, 2018. 2. 이상민.
There are limited data regarding serum activin-A as a biomarker for ARDS. We
aimed to evaluate whether serum activin-A levels are elevated and it has any role in
predicting severity and prognosis in ARDS patients.
Retrospective cohort study was performed with patients who were admitted to
MICU with diagnosis of ARDS and have serum samples stored within 48 hours of
ICU admission between March 2013 and December 2016 at a single tertiary
referral hospital. Serum activin-A levels were measured with ELISA kit, and were
compared with those of normal healthy control and non-ARDS sepsis patients.
Serum activin-A levels of total 97 patients with ARDS were measured. Levels of
Activin-A were elevated in ARDS patients compared to those of healthy controls
(2.34 vs. 2.89, p<0.001) and non-ARDS sepsis patients (2.73 vs. 2.89, p=0.002).
Activin-A was not correlated with severity of ARDS at the time of ICU admission,
but showed statistically significant correlation with in-hospital mortalities (Inhospital
survivors 676.2 vs. non-survivors 897.9, p=0.047). In predicting inhospital
mortality, serum activin-A concentrations showed superior AUC compared
to that of APACHE II scores (0.653
95% CI [0541, 0.765] vs. 0.591, 95% CI
[0.471, 0.710]). With cut-off level of 708pg/mL, those with high serum activin-A
levels had more than twofold increased risk of in-hospital mortalities.
Serum activin-A levels in ARDS patients are elevated. Those with high serum
activin-A levels tend to have poor prognosis.