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Probiotic fermentation augments the skin anti-photoaging properties of Agastache rugosa through up-regulating antioxidant components in UV-B-irradiated HaCaT keratinocytes
DC Field | Value | Language |
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dc.contributor.author | Shin, Daehyun | - |
dc.contributor.author | Lee, Yoonjin | - |
dc.contributor.author | Huang, Yu-Hua | - |
dc.contributor.author | Lim, Hye-Won | - |
dc.contributor.author | Jang, Kyounghee | - |
dc.contributor.author | Kim, Dae-Duk | - |
dc.contributor.author | Lim, Chang-Jin | - |
dc.date.accessioned | 2018-10-05T00:39:10Z | - |
dc.date.available | 2018-10-05T09:46:45Z | - |
dc.date.issued | 2018-06-26 | - |
dc.identifier.citation | BMC Complementary and Alternative Medicine, 18(1):196 | - |
dc.identifier.issn | 1472-6882 | - |
dc.identifier.uri | https://hdl.handle.net/10371/142837 | - |
dc.description.abstract | Background
Agastache rugosa (Fisch. & C.A.Mey.) Kuntze (Korean mint) is used to treat diverse types of human disorders in traditional medicine. In recent years, its non-fermented leaf extract (ARE) has been shown to possess protective properties against ultraviolet-B (UV-B) radiation-induced photooxidative stress. The present work aimed to examine whether probiotic bacterial fermentation would potentiate the skin anti-photoaging activity of ARE or not, by comparing the protective properties of ARE and corresponding fermented extract (ARE-F) against UV-B radiation-induced photooxidative stress in HaCaT keratinocytes. Methods ARE-F was produced from ARE by the fermentation with Lactobacillus rhamnosus HK-9, a type of Gram-positive probiotic bacterial strain. Anti-photoaging activities were evaluated by analyzing reactive oxygen species (ROS), promatrix metalloproteinases (proMMPs), total glutathione (GSH) and total superoxide dismutase (SOD) in UV-B-irradiated HaCaT keratinocytes. Antiradical activity was determined using 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assay. Results ARE-F contained higher attenuating activity on the UV-B-induced ROS generation than ARE. Similarly, ARE-F was able to diminish the UV-B-induced proMMP-9 and -2 more effectively than ARE. ARE-F displayed higher tendencies to augment the UV-B-reduced total GSH content and SOD activity than ARE. However, there were no significant difference between ARE and ARE-F in ABTS radical scavenging activities. Conclusions The findings suggest that the UV-B radiation-protective activity of ARE is enhanced by probiotic bacterial fermentation, which might improve the therapeutic and cosmetic values of A. rugosa leaves. | - |
dc.description.sponsorship | This study was supported by a grant of the Korean Health Technology R&D Project (Grant No.HN14C0081), the Ministry of Health & Welfare, Republic of Korea. | - |
dc.language.iso | en | - |
dc.subject | Agastache rugosa | - |
dc.subject | Anti-photoaging | - |
dc.subject | Glutathione | - |
dc.subject | HaCaT | - |
dc.subject | Matrix metalloproteinase (MMP) | - |
dc.subject | Probiotic fermentation | - |
dc.subject | Reactive oxygen species (ROS) | - |
dc.subject | Superoxide dismutase | - |
dc.title | Probiotic fermentation augments the skin anti-photoaging properties of Agastache rugosa through up-regulating antioxidant components in UV-B-irradiated HaCaT keratinocytes | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 신대현 | - |
dc.contributor.AlternativeAuthor | 이윤진 | - |
dc.contributor.AlternativeAuthor | 황유화 | - |
dc.contributor.AlternativeAuthor | 임혜원 | - |
dc.contributor.AlternativeAuthor | 장경희 | - |
dc.contributor.AlternativeAuthor | 김대덕 | - |
dc.contributor.AlternativeAuthor | 임창진 | - |
dc.identifier.doi | 10.1186/s12906-018-2194-9 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2018-07-01T04:40:17Z | - |
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