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IgG4-related ophthalmic disease involving extraocular muscles: case series
Cited 6 time in
Web of Science
Cited 7 time in Scopus
- Authors
- Issue Date
- 2018-07-03
- Publisher
- BioMed Central
- Citation
- BMC Ophthalmology, 18(1):162
- Keywords
- Strabismus ; IgG4-related ophthalmic disease ; Extraocular muscle ; Imaging findings ; Case report
- Abstract
- Background
To elucidate the clinical features of strabismus associated with IgG4-related ophthalmic disease (IgG4-ROD).
Case summary
All of the four patients with IgG4-ROD showed marked enlargement of the extraocular muscles, however, two patients showed orthotropia with full ductions and versions. One patient showed a small angle of exotropia and hypertropia of less than 5 prism diopters. One remaining patient showed orthotropia, full ductions and versions despite marked enlargement of the extraocular muscles, then developed hypertropia up to 35 prism diopters with activation of inflammation, which promptly improved after treatment with oral steroids.
Conclusions
IgG4-ROD usually shows normal ocular motility despite extraocular muscle enlargement, which is the key distinguishing feature from other orbital inflammatory diseases. Active flare-up with increased serum IgG4 levels may produce a large angle of eye deviation, but mostly respond well to steroid treatment.
- ISSN
- 1471-2415
- Language
- English
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