Respiratory severity score as a predictive factor for the mortality of congenital diaphragmatic hernia
선천성 횡격막 탈장의 사망률에 대한 예측 인자로서의 Respiratory severity score

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의과대학 의학과
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서울대학교 대학원
학위논문 (석사)-- 서울대학교 대학원 : 의과대학 의학과, 2018. 8. 김한석.
Background: Congenital diaphragmatic hernia (CDH) is rare but potentially fatal. The overall outcome is highly variable. This study aimed to identify a simple and dynamic parameter that helps predict the mortality of CDH patients in real time without invasive tests.

Methods: We conducted a retrospective chart review of 59 CDH cases. Maternal and fetal information included the gestational age at diagnosis, site of defect, presence of liver herniation, and lung-to-head ratio (LHR) at 20-29 weeks of gestational age. Information regarding postnatal treatment, including the number of days until surgery, the need for inhaled nitric oxide (iNO), the need for extracorporeal membrane oxygenation (ECMO), and survival, was collected. The highest respiratory severity score (RSS) within 24 h after birth was also calculated.

Results: Statistical analysis showed that a younger gestational age at initial diagnosis (P < 0.001), a lower LHR (P = 0.001), and the presence of liver herniation (P = 0.003) were prenatal risk factors for CDH mortality. The highest RSS within 24 h after birth and use of iNO and ECMO were significant factors affecting survival. In the multivariate analysis, the only remaining significant risk factor was the highest preoperative RSS within 24 h after birth (P = 0.002). The area under the ROC curve was 0.9375 with a sensitivity of 91.67% and specificity of 83.87% at the RSS cut-off value of 5.2. The positive and negative predictive values were 82.14% and 92.86%, respectively.

Conclusion: Using the RSS as a prognostic predictor with simple calculations will help clinicians plan CDH patient management.
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Theses (Master's Degree_의학과)
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