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The association of tumor necrosis factor superfamily 13 with recurrence of immunoglobulin A nephropathy in living related kidney transplantation

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Authors
Jo, Hyung Ah; Han, Seung Seok; Lee, Sunhwa; Kim, Joo Young; Yang, Seung Hee; Lee, Hajeong; Yang, Jae Seok; Lee, Jung Pyo; Joo, Kwon Wook; Lim, Chun Soo; Kim, Yon Su; Ahn, Curie; Han, Jin Suk; Kim, Dong Ki
Issue Date
2019-01-31
Publisher
BioMed Central
Citation
BMC Nephrology. 2019 Jan 31;20(1):33
Keywords
IgA nephropathyTumor necrosis factor superfamily 13Recurrence
Abstract
Background
An increasing amount of evidence has demonstrated an association between an increase in the level of tumor necrosis factor superfamily 13 (TNFSF13) and immunoglobulin A nephropathy (IgAN) progression. We aimed to evaluate if the level of pre-transplant serum TNFSF13 is predictive of IgAN recurrence after kidney transplantation.

Methods
This analysis was based on the clinical and laboratory data of 69 patients with IgAN who underwent first kidney transplantation with no evidence of mesangial IgA deposits in zero-time transplantation biopsy. We measured pre-transplant serum TNFSF13, total IgA, and galactose-deficient IgA1 levels.

Results
The recurrence rate of IgAN over a median follow-up duration of 5.1 years was 15.9% (11/69 patients), with a mean time to the first recurrence of 1.7 years. The high pre-transplant TNFSF13 level was associated with IgAN recurrence after kidney transplantation among patients who received a graft from a living related donor.

Conclusions
This study highlights association of TNFSF13 levels in recurrent IgAN patients who undergo living related donor transplantation. Further research is needed to clarify mechanisms by which TNFSF13 affects the recurrence of IgA nephropathy.
ISSN
1471-2369
Language
English
URI
http://hdl.handle.net/10371/147146
DOI
https://doi.org/10.1186/s12882-019-1222-4
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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