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Generation, culture, and differentiation of human embryonic stem cells for therapeutic applications
Cited 40 time in
Web of Science
Cited 44 time in Scopus
- Authors
- Issue Date
- 2005-10-26
- Publisher
- Elsevier
- Citation
- Mol Ther. 2006 Jan;13(1):5-14. Epub 2005 Oct 20.
- Keywords
- Cell Lineage ; Cells, Cultured ; Animals ; Blastocyst/*cytology ; Gene Therapy ; Germ Layers/*cytology ; Humans ; Mice ; Stem Cell Transplantation ; Stem Cells/*cytology ; Cell Differentiation
- Abstract
- Embryonic stem (ES) cells, derived from the inner cell mass of the mammalian blastocyst, can continuously proliferate in an undifferentiated state and can also be induced to differentiate into a desired cell lineage. These abilities make ES cells an appealing source for cell replacement therapies, the study of developmental biology, and drug/toxin screening studies. As compared to mouse ES cells, human ES cells have only recently been derived and studied. Although there are many differences in properties between mouse and human ES cells, the study of mouse ES cells has provided important insights into human ES cell research. In this review, we describe the advantages and disadvantages of methods used for human ES cell derivation, the expansion of human ES cells, and the current status of human ES cell differentiation research. In addition, we discuss the endeavor that scientists have undertaken toward the therapeutic application of these cells, which includes therapeutic cloning and the improvement of human ES cell culture conditions.
- ISSN
- 1525-0016 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16242999
https://hdl.handle.net/10371/14768
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