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Cytokinetics of secondary neurulation in chick embryos: Hamburger and Hamilton stages 16-45

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Authors
Yang, Hee-Jin; Wang, Kyu-Chang; Chi, Je G; Lee, Myung-Sook; Lee, Yun-Jin; Kim, Seung-Ki; Lee, Chang Sub; Cho, Byung-Kyu
Issue Date
2006-03-21
Publisher
Springer-Verlag
Citation
Childs Nerv Syst. 2006 Jun;22(6):567-71. Epub 2006 Mar 18.
Keywords
Age FactorsAnimalsApoptosis/physiologyCell DifferentiationCentral Nervous System/*cytology/*embryologyChick EmbryoCytokinesis/*physiologyEmbryonic Development/*physiologyImmunohistochemistry/methodsIn Situ Nick-End Labeling/methodsNeurons/*physiologyProliferating Cell Nuclear Antigen/metabolism
Abstract
OBJECTIVES: In an attempt to understand the events in the secondary neurulation in embryonic stage, we investigated cytokinetic changes in the tail bud of normal developing chick embryos. MATERIALS AND METHODS: We investigated chick embryos of Hamburger and Hamilton stages 16-45 by staining for proliferating cell nuclear antigen (PCNA) and applying the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) method. RESULTS AND CONCLUSIONS: The cytokinetics of secondary neurulation have several distinctive properties: a general chronological delay compared to primary neurulation; absence of ventrodorsal differences; larger rostrocaudal differences; and degeneration of the distal end of the spinal cord in the later stages of development. These differences in morphogenetic and cytokinetic behavior between primary and secondary neurulation may help to improve our understanding of anomalies originating during secondary neurulation.
ISSN
0256-7040 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16547762

http://hdl.handle.net/10371/15096
DOI
https://doi.org/10.1007/s00381-006-0087-6
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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