Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin

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Roh, Jong-Lyel; Sung, Myung-Whun; Kim, Kwang Hyun
Issue Date
John Wiley & Sons
Head Neck. 2005 Apr;27(4):326-32.
AnimalsAnti-Inflammatory Agents, Non-Steroidal/*therapeutic useCarcinoma/pathology/*prevention & controlCarcinoma, Squamous Cell/pathology/*prevention & controlCell Line, TumorCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase Inhibitors/*therapeutic useDisease Models, AnimalIndomethacin/*therapeutic useMaleMelanoma/pathology/*prevention & controlMiceMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMice, Inbred StrainsMuscle, Skeletal/*surgeryNeoplasm Recurrence, Local/prevention & controlNeoplasm SeedingNeoplasm TransplantationPeroxidases/antagonists & inhibitorsProstaglandin-Endoperoxide Synthases/drug effectsPyrazoles/*therapeutic useSulfonamides/*therapeutic use
BACKGROUND: Tumor growth is accelerated in surgical wounds. However, few experiments seeking to prevent such accelerated tumor growth have been performed. METHODS: We created surgical wounds in three syngeneic mice for the implantation of three murine cancer cell lines, SCC VII, CT-26, and B16F10. The tumor growth in the wound group was compared with that in non-wound-control mice. Celecoxib or indomethacin was administered to the mice that had tumor implanted into the surgical wound to observe the tumor-suppressive effect. RESULTS: The surgical wounds promoted tumor growth with different degrees, depending on the type of tumor. Such an accelerated tumor growth did not seem to be affected by cyclooxygenase-2 expression of tumors per se, but its mechanism needs to be explained by further studies. Celecoxib and indomethacin had a significant inhibitory effect on the tumor growth in the surgical wound. This suppressive effect is most obvious when celecoxib is administered daily from 1 day before surgical wounding and tumor implantation. CONCLUSION: Our results can justify that the preventive use of celecoxib in patients in whom local recurrence by tumor contamination is predicted.
1043-3074 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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