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Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Roh, Jong-Lyel | - |
dc.contributor.author | Sung, Myung-Whun | - |
dc.contributor.author | Kim, Kwang Hyun | - |
dc.date.accessioned | 2009-11-25T04:12:20Z | - |
dc.date.available | 2009-11-25T04:12:20Z | - |
dc.date.issued | 2005-02-19 | - |
dc.identifier.citation | Head Neck. 2005 Apr;27(4):326-32. | en |
dc.identifier.issn | 1043-3074 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15719392 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15210 | - |
dc.description.abstract | BACKGROUND: Tumor growth is accelerated in surgical wounds. However, few experiments seeking to prevent such accelerated tumor growth have been performed. METHODS: We created surgical wounds in three syngeneic mice for the implantation of three murine cancer cell lines, SCC VII, CT-26, and B16F10. The tumor growth in the wound group was compared with that in non-wound-control mice. Celecoxib or indomethacin was administered to the mice that had tumor implanted into the surgical wound to observe the tumor-suppressive effect. RESULTS: The surgical wounds promoted tumor growth with different degrees, depending on the type of tumor. Such an accelerated tumor growth did not seem to be affected by cyclooxygenase-2 expression of tumors per se, but its mechanism needs to be explained by further studies. Celecoxib and indomethacin had a significant inhibitory effect on the tumor growth in the surgical wound. This suppressive effect is most obvious when celecoxib is administered daily from 1 day before surgical wounding and tumor implantation. CONCLUSION: Our results can justify that the preventive use of celecoxib in patients in whom local recurrence by tumor contamination is predicted. | en |
dc.language.iso | en | en |
dc.publisher | John Wiley & Sons | en |
dc.subject | Animals | en |
dc.subject | Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use | en |
dc.subject | Carcinoma/pathology/*prevention & control | en |
dc.subject | Carcinoma, Squamous Cell/pathology/*prevention & control | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Cyclooxygenase 2 | en |
dc.subject | Cyclooxygenase 2 Inhibitors | en |
dc.subject | Cyclooxygenase Inhibitors/*therapeutic use | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Indomethacin/*therapeutic use | en |
dc.subject | Male | en |
dc.subject | Melanoma/pathology/*prevention & control | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred BALB C | en |
dc.subject | Mice, Inbred C3H | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Mice, Inbred Strains | en |
dc.subject | Muscle, Skeletal/*surgery | en |
dc.subject | Neoplasm Recurrence, Local/prevention & control | en |
dc.subject | Neoplasm Seeding | en |
dc.subject | Neoplasm Transplantation | en |
dc.subject | Peroxidases/antagonists & inhibitors | en |
dc.subject | Prostaglandin-Endoperoxide Synthases/drug effects | en |
dc.subject | Pyrazoles/*therapeutic use | en |
dc.subject | Sulfonamides/*therapeutic use | en |
dc.title | Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 노종렬 | - |
dc.contributor.AlternativeAuthor | 성명훈 | - |
dc.contributor.AlternativeAuthor | 김광현 | - |
dc.identifier.doi | 10.1002/hed.20167 | - |
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