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Suppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacin

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dc.contributor.authorRoh, Jong-Lyel-
dc.contributor.authorSung, Myung-Whun-
dc.contributor.authorKim, Kwang Hyun-
dc.date.accessioned2009-11-25T04:12:20Z-
dc.date.available2009-11-25T04:12:20Z-
dc.date.issued2005-02-19-
dc.identifier.citationHead Neck. 2005 Apr;27(4):326-32.en
dc.identifier.issn1043-3074 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15719392-
dc.identifier.urihttps://hdl.handle.net/10371/15210-
dc.description.abstractBACKGROUND: Tumor growth is accelerated in surgical wounds. However, few experiments seeking to prevent such accelerated tumor growth have been performed. METHODS: We created surgical wounds in three syngeneic mice for the implantation of three murine cancer cell lines, SCC VII, CT-26, and B16F10. The tumor growth in the wound group was compared with that in non-wound-control mice. Celecoxib or indomethacin was administered to the mice that had tumor implanted into the surgical wound to observe the tumor-suppressive effect. RESULTS: The surgical wounds promoted tumor growth with different degrees, depending on the type of tumor. Such an accelerated tumor growth did not seem to be affected by cyclooxygenase-2 expression of tumors per se, but its mechanism needs to be explained by further studies. Celecoxib and indomethacin had a significant inhibitory effect on the tumor growth in the surgical wound. This suppressive effect is most obvious when celecoxib is administered daily from 1 day before surgical wounding and tumor implantation. CONCLUSION: Our results can justify that the preventive use of celecoxib in patients in whom local recurrence by tumor contamination is predicted.en
dc.language.isoenen
dc.publisherJohn Wiley & Sonsen
dc.subjectAnimalsen
dc.subjectAnti-Inflammatory Agents, Non-Steroidal/*therapeutic useen
dc.subjectCarcinoma/pathology/*prevention & controlen
dc.subjectCarcinoma, Squamous Cell/pathology/*prevention & controlen
dc.subjectCell Line, Tumoren
dc.subjectCyclooxygenase 2en
dc.subjectCyclooxygenase 2 Inhibitorsen
dc.subjectCyclooxygenase Inhibitors/*therapeutic useen
dc.subjectDisease Models, Animalen
dc.subjectIndomethacin/*therapeutic useen
dc.subjectMaleen
dc.subjectMelanoma/pathology/*prevention & controlen
dc.subjectMiceen
dc.subjectMice, Inbred BALB Cen
dc.subjectMice, Inbred C3Hen
dc.subjectMice, Inbred C57BLen
dc.subjectMice, Inbred Strainsen
dc.subjectMuscle, Skeletal/*surgeryen
dc.subjectNeoplasm Recurrence, Local/prevention & controlen
dc.subjectNeoplasm Seedingen
dc.subjectNeoplasm Transplantationen
dc.subjectPeroxidases/antagonists & inhibitorsen
dc.subjectProstaglandin-Endoperoxide Synthases/drug effectsen
dc.subjectPyrazoles/*therapeutic useen
dc.subjectSulfonamides/*therapeutic useen
dc.titleSuppression of accelerated tumor growth in surgical wounds by celecoxib and indomethacinen
dc.typeArticleen
dc.contributor.AlternativeAuthor노종렬-
dc.contributor.AlternativeAuthor성명훈-
dc.contributor.AlternativeAuthor김광현-
dc.identifier.doi10.1002/hed.20167-
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