Systemic chemotherapy in patients with indwelling ureteral stenting

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Oh, Seung-June; Ku, Ja Hyeon; Byun, Seok-Soo; Lee, Sang Wook; Jeon, Hwang Gyun; Kim, Hyeon Hoe
Issue Date
Blackwell Publishing
Int J Urol. 2005 Jun;12(6):548-51.
Acute DiseaseAdultAgedAged, 80 and overAntineoplastic Agents/*adverse effects/therapeutic useEquipment DesignFemaleFever/epidemiology/etiologyHumansIncidenceMaleMiddle AgedNeoplasms/*complications/*drug therapyPyelonephritis/epidemiology/*etiologyRetrospective StudiesRisk FactorsStents/*adverse effectsTime FactorsUreteral Obstruction/etiology/*surgeryUrinary Diversion/*methods
BACKGROUND: We investigated whether systemic chemotherapy increased episodes of acute pyelonephritis (APN) in patients with an indwelling double-J stent due to non-urological malignant ureteral obstruction. METHODS: A retrospective study was performed on a total of 74 patients (16 men and 58 women; median age, 53.0; range, 34-84 years) with non-urological malignant ureteral obstruction, who were managed by double-J stenting between October 1997 and December 2001. The patients were divided into those who received (33 patients, group I) and those who did not receive systemic chemotherapy (41 patients, group II) during the stent indwelling period (median, 7.0; range, 1-44 month). Routine antibiotic prophylaxis was not administered to any patient. Median follow-up was 10.5 (range, 1-45) months. Clinical features, including the incidence of febrility and APN, were compared between the two groups. RESULTS: Of the 74 patients, 18 patients (24.3%) experienced acute febrile episodes during ureteral stenting, but only five (6.8%) patients were diagnosed as having APN. No significant difference in the incidence of fever or APN was found between the two groups (P = 1.000 and P = 0.651, respectively). Univariate logistic analysis indicated that only the duration of follow-up was a risk factor for an episode of fever. Other parameters had no clinical significance. CONCLUSION: Our findings suggest that systemic chemotherapy may not predispose the risk of acute pyelonephritis in patients with an indwelling ureteral stent due to non-urological malignant ureteral obstruction.
0919-8172 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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