Outcomes of hepatic resection for a single large hepatocellular carcinoma

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Cho, Yong Beom; Lee, Kuhn Uk; Lee, Hae Won; Cho, Eung-Ho; Yang, Sung-Hoon; Cho, Jai Young; Yi, Nam-Joon; Suh, Kyung-Suk
Issue Date
Springer Verlag
World J Surg. 2007 Apr;31(4):795-801.
Carcinoma, Hepatocellular/mortality/*surgeryDisease-Free SurvivalFemaleHepatectomy/*methodsHumansLiver Neoplasms/mortality/*surgeryMaleMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalPostoperative ComplicationsPrognosisProportional Hazards ModelsSurvival RateTreatment Outcome
BACKGROUND: The proper role of surgical resection, given the various treatment modalities available, needs to be further clarified in patients with a single large hepatocellular carcinoma (HCC). To evaluate the role of surgical resection in this group of patients, we studied the long-term outcomes of patients that received hepatic resection for a single large (> 5-10 cm in diameter) HCC. METHODS: The clinicopathologic data and long-term outcomes of 61 patients with a single large HCC (> 5-10 cm in diameter; L group) were compared with those of 169 patients with a single small HCC (< or = 5 cm; S group). Prognostic factors were evaluated by univariate and multivariate analysis. RESULTS: Operative mortality rates were low in both groups (0.6% in group S and 1.6% in group L), and the incidence of postoperative hepatic failure was rare even in group L (1.6%). The cumulative 5-year overall survival rate in group S was 59.0%, whereas in group L it was 52.9% (p = 0.385), and the corresponding cumulative 5-year disease-free survival rates were 44.1% and 31.7%, respectively (p = 0.063). Child class B was found to predict poor overall and disease-free survival by multivariate analysis versus Child class A in both groups. The presence of microvascular invasion was also identified as a significant prognostic factor, but it only affected disease-free survival in the two groups. CONCLUSIONS: Single large HCCs do not require a large extent of hepatic resection and the associated increased risk of postoperative liver failure. The long-term survival of patients with a single large HCC is as good as that of patients with a single small HCC. We conclude that hepatic resection is a safe and effective therapy for single large HCCs.
0364-2313 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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