Outcomes of hepatic resection for a single large hepatocellular carcinoma

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dc.contributor.authorCho, Yong Beom-
dc.contributor.authorLee, Kuhn Uk-
dc.contributor.authorLee, Hae Won-
dc.contributor.authorCho, Eung-Ho-
dc.contributor.authorYang, Sung-Hoon-
dc.contributor.authorCho, Jai Young-
dc.contributor.authorYi, Nam-Joon-
dc.contributor.authorSuh, Kyung-Suk-
dc.identifier.citationWorld J Surg. 2007 Apr;31(4):795-801.en
dc.identifier.issn0364-2313 (Print)-
dc.description.abstractBACKGROUND: The proper role of surgical resection, given the various treatment modalities available, needs to be further clarified in patients with a single large hepatocellular carcinoma (HCC). To evaluate the role of surgical resection in this group of patients, we studied the long-term outcomes of patients that received hepatic resection for a single large (> 5-10 cm in diameter) HCC. METHODS: The clinicopathologic data and long-term outcomes of 61 patients with a single large HCC (> 5-10 cm in diameter; L group) were compared with those of 169 patients with a single small HCC (< or = 5 cm; S group). Prognostic factors were evaluated by univariate and multivariate analysis. RESULTS: Operative mortality rates were low in both groups (0.6% in group S and 1.6% in group L), and the incidence of postoperative hepatic failure was rare even in group L (1.6%). The cumulative 5-year overall survival rate in group S was 59.0%, whereas in group L it was 52.9% (p = 0.385), and the corresponding cumulative 5-year disease-free survival rates were 44.1% and 31.7%, respectively (p = 0.063). Child class B was found to predict poor overall and disease-free survival by multivariate analysis versus Child class A in both groups. The presence of microvascular invasion was also identified as a significant prognostic factor, but it only affected disease-free survival in the two groups. CONCLUSIONS: Single large HCCs do not require a large extent of hepatic resection and the associated increased risk of postoperative liver failure. The long-term survival of patients with a single large HCC is as good as that of patients with a single small HCC. We conclude that hepatic resection is a safe and effective therapy for single large HCCs.en
dc.publisherSpringer Verlagen
dc.subjectCarcinoma, Hepatocellular/mortality/*surgeryen
dc.subjectDisease-Free Survivalen
dc.subjectLiver Neoplasms/mortality/*surgeryen
dc.subjectMiddle Ageden
dc.subjectMultivariate Analysisen
dc.subjectNeoplasm Recurrence, Localen
dc.subjectPostoperative Complicationsen
dc.subjectProportional Hazards Modelsen
dc.subjectSurvival Rateen
dc.subjectTreatment Outcomeen
dc.titleOutcomes of hepatic resection for a single large hepatocellular carcinomaen
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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