Publications
Detailed Information
Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Soon-Tae | - |
dc.contributor.author | Chu, Kon | - |
dc.contributor.author | Park, Jung-Eun | - |
dc.contributor.author | Kang, Lami | - |
dc.contributor.author | Ko, Song-Yi | - |
dc.contributor.author | Jung, Keun-Hwa | - |
dc.contributor.author | Kim, Manho | - |
dc.date.accessioned | 2009-11-25T05:16:15Z | - |
dc.date.available | 2009-11-25T05:16:15Z | - |
dc.date.issued | 2006-09-09 | - |
dc.identifier.citation | Brain Res. 2006 Nov 6;1118(1):199-207. Epub 2006 Sep 7. | en |
dc.identifier.issn | 0006-8993 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16959224 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15282 | - |
dc.description.abstract | Huntington's disease has an increase in the activated calpain, which is enhanced by the NMDA receptor activation. We investigated the neuroprotective effect of memantine in 3-nitropropionic acid (3NP)-induced striatal degeneration model. Either memantine (20 mg/kg/day) or PBS was intraperitoneally administered for five days with 3NP continuous infusion. In the memantine-treated group, the striatal lesion volume, the number of TUNEL+ cells, and Fluoro-Jade C+ degenerating neurons were all decreased. Memantine increased Bcl-xl and decreased Bax level. Memantine also exerted an inhibitory effect on the micro-calpain level and decreased the huntingtin proteolytic fragments. Those rats treated with memantine showed less degree of weight loss at 5 days. Subsequently, memantine was found to have neuroprotective effects and save striatal cells with decreasing calpain levels in the 3NP model of Huntington's disease. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Apoptosis Regulatory Proteins/drug effects/metabolism | en |
dc.subject | Calpain/*drug effects/metabolism | en |
dc.subject | Cell Death/drug effects/physiology | en |
dc.subject | Corpus Striatum/*drug effects/pathology/physiopathology | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Down-Regulation/drug effects/physiology | en |
dc.subject | Excitatory Amino Acid Antagonists/pharmacology/therapeutic use | en |
dc.subject | Huntington Disease/*drug therapy/metabolism/physiopathology | en |
dc.subject | Male | en |
dc.subject | Memantine/*pharmacology/therapeutic use | en |
dc.subject | Nerve Degeneration/*drug therapy/physiopathology/prevention & control | en |
dc.subject | Nerve Tissue Proteins/drug effects/metabolism | en |
dc.subject | Neurons/*drug effects/metabolism/pathology | en |
dc.subject | Neuroprotective Agents/pharmacology | en |
dc.subject | Neurotoxins | en |
dc.subject | Nitro Compounds | en |
dc.subject | Nuclear Proteins/drug effects/metabolism | en |
dc.subject | Peptide Fragments/drug effects/metabolism | en |
dc.subject | Propionic Acids | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.title | Memantine reduces striatal cell death with decreasing calpain level in 3-nitropropionic model of Huntington's disease | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이순태 | - |
dc.contributor.AlternativeAuthor | 주건 | - |
dc.contributor.AlternativeAuthor | 박정은 | - |
dc.contributor.AlternativeAuthor | 강라미 | - |
dc.contributor.AlternativeAuthor | 고송이 | - |
dc.contributor.AlternativeAuthor | 정근화 | - |
dc.contributor.AlternativeAuthor | 김만호 | - |
dc.identifier.doi | 10.1016/j.brainres.2006.08.035 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.