Publications

Detailed Information

Synthetic biology for evolutionary engineering: from perturbation of genotype to acquisition of desired phenotype

DC Field Value Language
dc.contributor.authorYang, Jina-
dc.contributor.authorKim, Beomhee-
dc.contributor.authorKim, Gi Yeon-
dc.contributor.authorJung, Gyoo Yeol-
dc.contributor.authorSeo, Sang Woo-
dc.date.accessioned2019-06-12T08:32:53Z-
dc.date.available2019-06-12T17:34:34Z-
dc.date.issued2019-05-09-
dc.identifier.citationBiotechnology for Biofuels. 12(1):113ko_KR
dc.identifier.issn1754-6834-
dc.identifier.urihttps://hdl.handle.net/10371/153914-
dc.description.abstractWith the increased attention on bio-based industry, demands for techniques that enable fast and effective strain improvement have been dramatically increased. Evolutionary engineering, which is less dependent on biological information, has been applied to strain improvement. Currently, synthetic biology has made great innovations in evolutionary engineering, particularly in the development of synthetic tools for phenotypic perturbation. Furthermore, discovering biological parts with regulatory roles and devising novel genetic circuits have promoted high-throughput screening and selection. In this review, we first briefly explain basics of synthetic biology tools for mutagenesis and screening of improved variants, and then describe how these strategies have been improved and applied to phenotypic engineering. Evolutionary engineering using advanced synthetic biology tools will enable further innovation in phenotypic engineering through the development of novel genetic parts and assembly into well-designed logic circuits that perform complex tasks.ko_KR
dc.description.sponsorshipThis work was supported by the Bio & Medical Technology Development Program (NRF-2018M3A9H3020459) and the C1 Gas Refnery Program (NRF2016M3D3A1A01913561) through the National Research Foundation (NRF) funded by Ministry of Science and ICT (MSIT). JY was partially supported by Basic Science Research Program (NRF-2018R1C1B6005764) through the National Research Foundation (NRF) funded by MSIT and SWS was partially supported by Creative-Pioneering Researchers Program through Seoul National University (SNU).ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectSynthetic biologyko_KR
dc.subjectEvolutionary engineeringko_KR
dc.subjectBiosensorko_KR
dc.subjectCell factoryko_KR
dc.subjectDirected evolutionko_KR
dc.titleSynthetic biology for evolutionary engineering: from perturbation of genotype to acquisition of desired phenotypeko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor양지나-
dc.contributor.AlternativeAuthor김범희-
dc.contributor.AlternativeAuthor김기연-
dc.contributor.AlternativeAuthor정규열-
dc.contributor.AlternativeAuthor서상-
dc.identifier.doi10.1186/s13068-019-1460-5-
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.date.updated2019-05-12T20:36:47Z-
Appears in Collections:
Files in This Item:

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share