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Synthetic biology for evolutionary engineering: from perturbation of genotype to acquisition of desired phenotype
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Jina | - |
dc.contributor.author | Kim, Beomhee | - |
dc.contributor.author | Kim, Gi Yeon | - |
dc.contributor.author | Jung, Gyoo Yeol | - |
dc.contributor.author | Seo, Sang Woo | - |
dc.date.accessioned | 2019-06-12T08:32:53Z | - |
dc.date.available | 2019-06-12T17:34:34Z | - |
dc.date.issued | 2019-05-09 | - |
dc.identifier.citation | Biotechnology for Biofuels. 12(1):113 | ko_KR |
dc.identifier.issn | 1754-6834 | - |
dc.identifier.uri | https://hdl.handle.net/10371/153914 | - |
dc.description.abstract | With the increased attention on bio-based industry, demands for techniques that enable fast and effective strain improvement have been dramatically increased. Evolutionary engineering, which is less dependent on biological information, has been applied to strain improvement. Currently, synthetic biology has made great innovations in evolutionary engineering, particularly in the development of synthetic tools for phenotypic perturbation. Furthermore, discovering biological parts with regulatory roles and devising novel genetic circuits have promoted high-throughput screening and selection. In this review, we first briefly explain basics of synthetic biology tools for mutagenesis and screening of improved variants, and then describe how these strategies have been improved and applied to phenotypic engineering. Evolutionary engineering using advanced synthetic biology tools will enable further innovation in phenotypic engineering through the development of novel genetic parts and assembly into well-designed logic circuits that perform complex tasks. | ko_KR |
dc.description.sponsorship | This work was supported by the Bio & Medical Technology Development Program (NRF-2018M3A9H3020459) and the C1 Gas Refnery Program (NRF2016M3D3A1A01913561) through the National Research Foundation (NRF) funded by Ministry of Science and ICT (MSIT). JY was partially supported by Basic Science Research Program (NRF-2018R1C1B6005764) through the National Research Foundation (NRF) funded by MSIT and SWS was partially supported by Creative-Pioneering Researchers Program through Seoul National University (SNU). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Synthetic biology | ko_KR |
dc.subject | Evolutionary engineering | ko_KR |
dc.subject | Biosensor | ko_KR |
dc.subject | Cell factory | ko_KR |
dc.subject | Directed evolution | ko_KR |
dc.title | Synthetic biology for evolutionary engineering: from perturbation of genotype to acquisition of desired phenotype | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 양지나 | - |
dc.contributor.AlternativeAuthor | 김범희 | - |
dc.contributor.AlternativeAuthor | 김기연 | - |
dc.contributor.AlternativeAuthor | 정규열 | - |
dc.contributor.AlternativeAuthor | 서상 | - |
dc.identifier.doi | 10.1186/s13068-019-1460-5 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2019-05-12T20:36:47Z | - |
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