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Blood amyloid-β oligomerization associated with neurodegeneration of Alzheimer’s disease

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Authors
Youn, Young Chul; Kang, Sungmin; Suh, Jeewon; Park, Young Ho; Kang, Min Ju; Pyun, Jung-Min; Choi, Seong Hye; Jeong, Jee Hyang; Park, Kyung Won; Lee, Ho-Won; An, Seong Soo A.; Dominguez, Jacqueline C; Kim, SangYun
Issue Date
2019-05-10
Publisher
BioMed Central
Citation
Alzheimer's Research & Therapy. 11(1):40
Keywords
OligomerizationBlood-based biomarkerAmyloid βOligomerMultimer detection systemVoxelbased morphometryMultimer detection system-oligomeric Aβ
Abstract
Introduction
Oligomeric amyloid-ß is a major toxic species associated with Alzheimer’s disease pathogenesis. Methods used to measure oligomeric amyloid-β in the blood have increased in number in recent years. The Multimer Detection System-Oligomeric Amyloid-β (MDS-OAβ) is a specific method to measure oligomerization tendencies in the blood. The objective of this study was to determine the association between amyloid-ß oligomerization in the plasma and structural changes of the brain.

Methods
We studied 162 subjects composed of 92 community-based normal healthy subjects, 17 with subjective cognitive decline, 14 with mild cognitive impairment and 39 with Alzheimer’s disease dementia. All subjects underwent MDS-OAβ and three-dimensional T1 magnetic resonance imaging. To determine the structural changes of the brain that are statistically correlated with MDS-OAβ level, we used voxel-based morphometry with corrections for age and total intracranial volume covariates.

Results
We found brain volume reduction in the bilateral temporal, amygdala, parahippocampal and lower parietal lobe and left cingulate and precuneus regions (family-wise error, p < 0.05). Reduction was also found in white matter in proximity to the left temporal and bilateral lower parietal lobes and posterior corpus callosum (family-wise error, p < 0.05). Brain volume increment was not observed in any regions within grey or white matter.

Discussion
Findings suggest that substantial correlation exists between amyloid ß oligomerization in the blood and brain volume reduction in the form of Alzheimer’s disease despite of uncertainty in the casual relationship.
ISSN
1758-9193
Language
English
URI
http://hdl.handle.net/10371/153916
DOI
https://doi.org/10.1186/s13195-019-0499-7
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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