Bahamaolides A-B, Novel antifungal-macrocyclic lactones from marine actinomycete, streptomyces sp. CNQ343

Abstract

Two new 36-membered macrocyclic lactones, designated to be bahamaolides A and B, were isolated from the culture broth of the marine actinomycete Streptomyces sp. derived from a sediment sample collected at North Cat Bay in the Bahamas. The planar structures of bahamaolides A-B, bearing a hexaenone and nine consecutive skipped hydroxy groups, were determined by a combination of 1D and 2D NMR, mass, IR, and UV spectra. The absolute configurations of these compounds were established based on the multiple-step chemical reactions and spectroscopic analysis. Bahamaolides displayed significant inhibitory activity against Candida albicans-isocitrate lyase.