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Influences of Hyaluronic Acid on the Anticandidal Activities of Lysozyme and the Peroxidase System

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Authors
강정현
Advisor
고홍섭
Major
치의학과
Issue Date
2012-02
Publisher
서울대학교 대학원
Description
학위논문 (석사)-- 서울대학교 대학원 : 치의학과, 2012. 2. 고홍섭.
Abstract
OBJECTIVES: To investigate the fungistatic and fungicidal activity of hyaluronic acid (HA), and the influences of HA on the anticandidal activities of lysozyme and the peroxidase system.

MATERIALS AND METHODS: HA, hen egg-white lysozyme, and the bovine lactoperoxidase system were used. Candida albicans ATCC 10231, 18804, and 11006 strains were used in the experiments. The fungistatic activity of HA was determined by measuring the optical densities of the cultures. The candidacidal activity of HA and the influences of HA on the candidacidal activities of lysozyme and the peroxidase system were determined by comparing the numbers of colony forming units.
RESULTS: HA displayed inhibitory effects on the growth of C. albicans, and the inhibitory effects were proportional to HA concentration. HA did not have any measurable candidacidal activity. HA showed inhibitory effects on the candidacidal activities of lysozyme and the peroxidase system that was proportional to HA concentration. HA at 1.0 - 2.0 mg/mL almost completely inhibited the candidacidal activities of lysozyme and the peroxidase system.

CONCLUSIONS: HA possesses fungistatic activity but no candidacidal activity. HA showed inhibitory effects on the candidacidal activities of lysozyme and the peroxidase system.
Language
eng
URI
http://hdl.handle.net/10371/155697

http://dcollection.snu.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000001690
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Theses (Master's Degree_치의학과)
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