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Hearing preservation after gamma knife stereotactic radiosurgery of vestibular schwannoma
DC Field | Value | Language |
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dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Chung, Hyun-Tai | - |
dc.contributor.author | Jeong, Sang Soon | - |
dc.contributor.author | Park, Chul-Kee | - |
dc.contributor.author | Kim, Chae-Yong | - |
dc.contributor.author | Kim, Jeong Eun | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Jung, Hee-Won | - |
dc.date.accessioned | 2009-11-26 | - |
dc.date.available | 2009-11-26 | - |
dc.date.issued | 2005-06-14 | - |
dc.identifier.citation | Cancer. 2005 Aug 1;104(3):580-90. | en |
dc.identifier.issn | 0008-543X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15952200 | - |
dc.identifier.uri | https://hdl.handle.net/10371/15569 | - |
dc.description.abstract | BACKGROUND: To evaluate the hearing preservation rate and to determine its prognostic factors after gamma knife (GK) stereotactic radiosurgery (SRS) in patients with vestibular schwannoma, the authors used a prospective study design to analyze these patients. METHODS: Between December 1997 and January 2002, 25 patients with vestibular schwannoma with serviceable hearing were enrolled in the current study. The median tumor volume was 3.0 cc (0.16-9.1 cc). The prescription dose was 12.0 +/- 0.7 gray at an isodose line of 49.8 +/- 1.1%. The tumor control rate and complications were evaluated by focusing on hearing preservation and its prognostic factors. RESULTS: Based on radiologic study, the tumor control rate was 92% during the median follow-up period of 45 months. The trigeminal and facial nerve preservation rates were 95% and 100%, respectively. Thirteen (52%) of the 25 patients preserved serviceable hearing and 9 (36%) patients retained their pre-GK G-R grade levels after GK SRS. However, 16 patients showed hearing deterioration > 20 dB within 3-6 months and this trend continued for 24 months after the treatment. The maximum radiotherapy dose delivered to the cochlear nucleus was the single, significant prognostic factor of hearing deterioration. CONCLUSIONS: The authors concluded that a more sophisticated strategy to prevent hearing deterioration during the first 6 months post-GK SRS is necessary to improve long-term hearing preservation. | en |
dc.language.iso | en | - |
dc.publisher | John Wiley & Sons | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Cochlear Nerve/*pathology | en |
dc.subject | Female | en |
dc.subject | Follow-Up Studies | en |
dc.subject | Hearing Loss/diagnosis/etiology/*prevention & control | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Neuroma, Acoustic/pathology/*surgery | en |
dc.subject | Postoperative Complications/diagnosis/etiology/*prevention & control | en |
dc.subject | Prospective Studies | en |
dc.subject | Stereotaxic Techniques | en |
dc.subject | Treatment Outcome | en |
dc.subject | Tumor Burden | en |
dc.subject | Radiosurgery | - |
dc.title | Hearing preservation after gamma knife stereotactic radiosurgery of vestibular schwannoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 백선하 | - |
dc.contributor.AlternativeAuthor | 정현태 | - |
dc.contributor.AlternativeAuthor | 정상훈 | - |
dc.contributor.AlternativeAuthor | 박철기 | - |
dc.contributor.AlternativeAuthor | 김재용 | - |
dc.contributor.AlternativeAuthor | 정희원 | - |
dc.identifier.doi | 10.1002/cncr.21190 | - |
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