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Pituitary adenoma with rich folliculo-stellate cells and mucin-producing epithelia arising in a 2-year-old girl

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Authors
Min, Hye Sook; Lee, Seung June; Kim, Seung-Ki; Park, Sung-Hye
Issue Date
2007-08-10
Publisher
Blackwell Publishing
Citation
Pathol Int. 2007 Sep;57(9):600-5.
Keywords
ACTH-Secreting Pituitary Adenoma/*pathology/secretion/surgeryChild, PreschoolCytoplasm/ultrastructureDisease ProgressionFemaleGlial Fibrillary Acidic Protein/metabolismHumansKeratins/metabolismMagnetic Resonance ImagingMucins/*secretionPituitary Neoplasms/*pathology/secretion/surgeryS100 Proteins/metabolismTomography, X-Ray ComputedTreatment OutcomeTumor Markers, Biological/metabolism
Abstract
Pituitary adenoma is a rare neoplasm in childhood, with prolactin and adrenocorticotropic hormone (ACTH)-secreting adenomas predominating in this age group. Herein is reported a case of an ACTH-producing macroadenoma with an unusual histology that occurred in a 2-year-old girl. Because of the patient's age and the macroadenoma's suprasellar location and large size (up to 4 cm in diameter), radical surgery was performed under the suspicion of craniopharyngioma or germ-cell tumor. Pathologically, it was a unique pituitary adenoma composed of monotonous ACTH-producing cells, smaller folliculo-stellate cells (FSC), and mucin-producing cells. The FSC, non-hormone-secreting pituitary cells of uncertain function, were confirmed by their S-100 protein, glial fibrillary acidic protein and cytokeratin expression immunoprofiles. The abrupt transition between the prominent gland-forming mucin-producing epithelia and the FSC component suggested that the mucin-producing epithelia might be derived from the FSC. This association might represent so-called 'retrodifferentiation' of adenoma cells to the FSC and the precursor cells of Rathke's pouch.
ISSN
1320-5463 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17685932

http://hdl.handle.net/10371/15603
DOI
https://doi.org/10.1111/j.1440-1827.2007.02145.x
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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