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Impact of Pneumocystis jirovecii pneumonia on kidney transplant outcome
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Ji Eun | - |
dc.contributor.author | Han, Ahram | - |
dc.contributor.author | Lee, Hajeong | - |
dc.contributor.author | Ha, Jongwon | - |
dc.contributor.author | Kim, Yon Su | - |
dc.contributor.author | Han, Seung Seok | - |
dc.date.accessioned | 2019-07-01T06:02:25Z | - |
dc.date.available | 2019-07-01T15:03:33Z | - |
dc.date.issued | 2019-06-10 | - |
dc.identifier.citation | BMC Nephrology. 20(1):212 | ko_KR |
dc.identifier.issn | 1471-2369 | - |
dc.identifier.uri | https://hdl.handle.net/10371/156078 | - |
dc.description.abstract | Backgrounds
Pneumocystis jirovecii pneumonia (PCP) remains an important cause of morbidity and mortality in kidney transplant recipients. While the acute phase toxicity in patients with PCP is well-characterized, there is a lack of data on the effects of PCP on long-term graft outcome. Method This retrospective observational study analyzed 1502 adult patients who underwent kidney transplantation at Seoul National University Hospital between 2000 and 2017. After a propensity score matching was performed, the graft and survival outcomes were compared between PCP-negative and PCP-positive groups. Results A total of 68 patients (4.5%) developed PCP after transplantation. The multivariable Cox analysis showed that positivity for cytomegalovirus and lack of initial oral antibiotic prophylaxis were risk factors of post-transplant PCP. The PCP-positive group had higher hazard ratios of graft failure [adjusted hazard ratio (HR), 3.1 (1.14–8.26); P = 0.027] and mortality [adjusted HR, 11.0 (3.68–32.80); P < 0.001] than the PCP-negative group. However, the PCP event was not related with subsequent development of de novo donor-specific antibodies or pathologic findings, such as T-cell or antibody mediated rejection and interstitial fibrosis and tubular atrophy. Conclusions PCP is a risk factor of long-term graft failure and mortality, irrespective of rejection. Accordingly, appropriate prophylaxis and treatment is needed to avoid adverse transplant outcomes of PCP. | ko_KR |
dc.description.sponsorship | This study was supported by the Young Investigator Research Grant from the Korean Society Nephrology (Kyowa Hakko Kirin 2017) and a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education (NRF-2017R1D1A1B03031642). The grants had neither role in the study design, nor in data collection, analysis, interpretation and nor in manuscript writing. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Kidney transplantation | ko_KR |
dc.subject | Mortality | ko_KR |
dc.subject | Outcome | ko_KR |
dc.subject | Pneumocystis jirovecii | ko_KR |
dc.subject | Rejection | ko_KR |
dc.title | Impact of Pneumocystis jirovecii pneumonia on kidney transplant outcome | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김지은 | - |
dc.contributor.AlternativeAuthor | 한아람 | - |
dc.contributor.AlternativeAuthor | 이하정 | - |
dc.contributor.AlternativeAuthor | 하종원 | - |
dc.contributor.AlternativeAuthor | 김연수 | - |
dc.contributor.AlternativeAuthor | 한승석 | - |
dc.identifier.doi | 10.1186/s12882-019-1407-x | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2019-06-16T03:59:03Z | - |
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