SHERP

Predictors of paravalvular aortic regurgitation after surgery for Behcet’s disease-related severe aortic regurgitation

DC Field Value Language
dc.contributor.authorChoi, Hong-Mi-
dc.contributor.authorKim, Hyung-Kwan-
dc.contributor.authorPark, Sung-Ji-
dc.contributor.authorLee, Hyun-Jung-
dc.contributor.authorYoon, Yeonyee E.-
dc.contributor.authorPark, Jun-Bean-
dc.contributor.authorKim, Yong-Jin-
dc.contributor.authorCho, Goo-Young-
dc.contributor.authorHwang, In-Chang-
dc.contributor.authorSohn, Dae-Won-
dc.contributor.authorOh, Jae K-
dc.date.accessioned2019-07-01T06:34:15Z-
dc.date.available2019-07-01T15:35:11Z-
dc.date.issued2019-06-10-
dc.identifier.citationOrphanet Journal of Rare Diseases. 14(1):132ko_KR
dc.identifier.issn1750-1172-
dc.identifier.urihttp://hdl.handle.net/10371/156082-
dc.description.abstractBackground
Behcet’s disease (BD)-related aortic regurgitation (AR) is known to be associated with paravalvular leakage (PVL) after successful aortic valve (AV) surgery. This study aimed to determine predictors of PVL after successful AV surgery in BD patients. We retrospectively collected data of 35 patients (42.1 ± 9.1 years, 27 men) who underwent surgery for severe BD-related AR at two tertiary centers. The diagnosis was established based on echocardiographic, surgical, and/or pathological findings in conjunction with the International Study Group criteria for BD. A total of 76 cases of AV surgery in 35 patients were analyzed.

Results
A median follow-up duration was 8.0 years (interquartile range, 5.4–14.3 years). PVL developed in 18 patients (51.4%) within 2 years after the first surgery. Six patients who met the diagnostic criteria for BD did not develop PVL, in whom 5 patients took immunosuppressive therapy (IST). However, 4 of 9 patients (44.4%) who did not meet the diagnostic criteria developed PVL, in whom four (44.4%) patients took IST. On multivariable analysis, postoperative IST and concomitant aortic root replacement (ARR) were two independent predictors for less PVL development (HR 0.38, 95% CI 0.17–0.89, p = 0.025 for postoperative IST; HR 0.17, 95% CI 0.08–0.36, p < 0.001 for concomitant ARR). Preoperative IST use did not determine PVL development (p = 0.75).

Conclusions
Postoperative, but not preoperative, IST and concomitant ARR were independent predictors of less development of PVL. Special attention is required for early diagnosis BD-related AR, especially in patients not satisfying the current diagnostic criteria.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectBehcet’s diseaseko_KR
dc.subjectAortic regurgitationko_KR
dc.subjectParavalvular leakageko_KR
dc.subjectAortic valve surgeryko_KR
dc.titlePredictors of paravalvular aortic regurgitation after surgery for Behcet’s disease-related severe aortic regurgitationko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor최홍미-
dc.contributor.AlternativeAuthor김경환-
dc.contributor.AlternativeAuthor박승지-
dc.contributor.AlternativeAuthor이현정-
dc.contributor.AlternativeAuthor윤연이-
dc.contributor.AlternativeAuthor박준빈-
dc.contributor.AlternativeAuthor김용진-
dc.contributor.AlternativeAuthor조구영-
dc.contributor.AlternativeAuthor황인창-
dc.contributor.AlternativeAuthor손대-
dc.identifier.doi10.1186/s13023-019-1083-8-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2019-06-16T04:00:36Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
Files in This Item:
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse